ArticleNature2010
An intrinsic vasopressin system in the olfactory bulb is involved in social recognition.
Article in Nature, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
93 citing papers in PubMed, 1 synthesis or guideline pooled it, 215 citations in OpenAlex.
- The neuroscience of social feelings: mechanisms of adaptive social functioning.Neuroscience and biobehavioral reviews · 2021Pooled it
- Vasopressin enhances human preemptive strike in both males and females.Scientific reports · 2019Trial
- Oxytocin facilitates accurate perception of competition in men and kinship in women.Social cognitive and affective neuroscience · 2013Trial
- Single-Nucleus Transcriptomics of the Mouse Medial Preoptic Area Reveals Sex-Dependent Molecular Signatures of Social Dominance.bioRxiv : the preprint server for biology · 2026Article
- Sex-specific single transcript level atlas of vasopressin and its receptor (AVPR1a) in the mouse brain.eLife · 2026Article
- Circuit logic of oxytocin and vasopressin complementary actions.Frontiers in neuroscience · 2026Review
- Essential Role of the Anterior Piriform Cortex in Mediating Social Novelty Output via a Top-Down Circuit.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Molecular Interaction Between Vasopressin and Insulin in Regulation of Metabolism: Impact on Cardiovascular and Metabolic Diseases.International journal of molecular sciences · 2024Review
- Signaling mechanisms underlying activity-dependent integration of adult-born neurons in the mouse olfactory bulb.Genesis (New York, N.Y. : 2000) · 2024Review
- Vasopressin differentially modulates the excitability of rat olfactory bulb neuron subtypes.Frontiers in neural circuits · 2024Article
- Detection, processing and reinforcement of social cues: regulation by the oxytocin system.Nature reviews. Neuroscience · 2023Review
- Vasopressin as Possible Treatment Option in Autism Spectrum Disorder.Biomedicines · 2023Review
- Vasopressin receptor 1a, oxytocin receptor, and oxytocin knockout male and female mice display normal perceptual abilities towards non-social odorants.Hormones and behavior · 2023Article
- Modulation of social behavior by distinct vasopressin sources.Frontiers in endocrinology · 2023Review
- Characterization of anFrontiers in pharmacology · 2023Article
- Arginine Vasopressin, Synaptic Plasticity, and Brain Networks.Current neuropharmacology · 2022Review
- Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities.Endocrinology · 2022Review
- Rescue of Vasopressin Synthesis in Magnocellular Neurons of the Supraoptic Nucleus Normalises Acute Stress-Induced Adrenocorticotropin Secretion and Unmasks an Effect on Social Behaviour in Male Vasopressin-Deficient Brattleboro Rats.International journal of molecular sciences · 2022Article
- Conditional ablation of vasopressin-synthesizing neurons in transgenic rats.Journal of neuroendocrinology · 2021Article
- Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 6 institutions in 4 countries.
Funding
Abstract
Many peptides, when released as chemical messengers within the brain, have powerful influences on complex behaviours. Most strikingly, vasopressin and oxytocin, once thought of as circulating hormones whose actions were confined to peripheral organs, are now known to be released in the brain, where they have fundamentally important roles in social behaviours. In humans, disruptions of these peptide systems have been linked to several neurobehavioural disorders, including Prader-Willi syndrome, affective disorders and obsessive-compulsive disorder, and polymorphisms of V1a vasopressin receptor have been linked to autism. Here we report that the rat olfactory bulb contains a large population of interneurons which express vasopressin, that blocking the actions of vasopressin in the olfactory bulb impairs the social recognition abilities of rats and that vasopressin agonists and antagonists can modulate the processing of information by olfactory bulb neurons. The findings indicate that social information is processed in part by a vasopressin system intrinsic to the olfactory system.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.