ArticleJournal of neurophysiology2010
Multimodal sensory responses of nucleus reticularis gigantocellularis and the responses' relation to cortical and motor activation.
Article in Journal of neurophysiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 54 citations in OpenAlex.
- Noradrenaline Regulation of Brain-Body Communication.Advances in experimental medicine and biology · 2025Review
- Temporal relations between peripheral and central arousals in good and poor sleepers.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Kv2.1 expression in giant reticular neurons of the postnatal mouse brain.Journal of chemical neuroanatomy · 2021Article
- Potassium channels and the development of arousal-relevant action potential trains in primary hindbrain neurons.Brain research · 2021Article
- Molecular profiling of reticular gigantocellularis neurons indicates that eNOS modulates environmentally dependent levels of arousal.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The Feasibility of Encapsulated Embryonic Medullary Reticular Cells to Grow and Differentiate Into Neurons in Functionalized Gelatin-Based Hydrogels.Frontiers in materials · 2018Article
- The Brain Compass: A Perspective on How Self-Motion Updates the Head Direction Cell Attractor.Neuron · 2018Review
- How doctors diagnose diseases and prescribe treatments: an fMRI study of diagnostic salience.Scientific reports · 2017Article
- Ventral medullary control of rapid eye movement sleep and atonia.Experimental neurology · 2017Article
- Generalized CNS arousal: An elementary force within the vertebrate nervous system.Neuroscience and biobehavioral reviews · 2016Review
- Development of Electrophysiological Properties of Nucleus Gigantocellularis Neurons Correlated with Increased CNS Arousal.Developmental neuroscience · 2016Article
- Distribution of raphespinal fibers in the mouse spinal cord.Molecular pain · 2015Article
- Enhancement of sleep slow waves: underlying mechanisms and practical consequences.Frontiers in systems neuroscience · 2014Article
- Processing information related to centrally initiated locomotor and voluntary movements by feline spinocerebellar neurones.The Journal of physiology · 2011Article
- Quantitative descriptions of generalized arousal, an elementary function of the vertebrate brain.Proceedings of the National Academy of Sciences of the United States of America · 2011Review
- Impact of generalized brain arousal on sexual behavior.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
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3 authors at 1 institution in 1 country.
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Abstract
The connectivity of large neurons of the nucleus reticularis gigantocellularis (NRGc) in the medullary reticular formation potentially allows both for the integration of stimuli, in several modalities, that would demand immediate action, and for coordinated activation of cortical and motoric activity. We have simultaneously recorded cortical local field potentials, neck muscle electromyograph (EMG), and the neural activity of medullary NRGc neurons in unrestrained, unanesthetized rats to determine whether the activity of the NRGc is consistent with the modulation of general arousal. We observed excitatory responses of individual NRGc neurons to all modalities tested: tactile, visual, auditory, vestibular, and olfactory. Excitation was directly linked to increases in neck muscle EMG amplitude and corresponded with increases in the power of fast oscillations (30 to 80 Hz) of cortical activity and decreases in the power of slow oscillations (2 to 8 Hz). Because these reticular formation neurons can respond to broad ranges of stimuli with increased firing rates associated with the initiation of behavioral responses, we infer that they are part of an elementary "first responder" CNS arousal mechanism.
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