ArticleMolecular endocrinology (Baltimore, Md.)2010
Corepressors TLE1 and TLE3 interact with HESX1 and PROP1.
Article in Molecular endocrinology (Baltimore, Md.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Role of PROP1 in Postnatal Pituitary Gland Maturation.Endocrinology · 2025Article
- Gene Misexpression in aJournal of the Endocrine Society · 2024Article
- Characterization of a novelClinical case reports · 2017Article
- Foxo1 Is Required for Normal Somatotrope Differentiation.Endocrinology · 2016Article
- TLE3 represses colorectal cancer proliferation by inhibiting MAPK and AKT signaling pathways.Journal of experimental & clinical cancer research : CR · 2016Article
- HESX1 mutations in patients with congenital hypopituitarism: variable phenotypes with the same genotype.Clinical endocrinology · 2016Article
- The Groucho/Transducin-like enhancer of split protein family in animal development.IUBMB life · 2015Review
- Homeodomain Proteins SIX3 and SIX6 Regulate Gonadotrope-specific Genes During Pituitary Development.Molecular endocrinology (Baltimore, Md.) · 2015Article
- Genetic regulation of murine pituitary development.Journal of molecular endocrinology · 2015Review
- Msx1 homeodomain protein represses the αGSU and GnRH receptor genes during gonadotrope development.Molecular endocrinology (Baltimore, Md.) · 2013Article
- Review
- Role of gonadotropin regulated testicular RNA helicase (GRTH/Ddx25) on polysomal associated mRNAs in mouse testis.PloS one · 2012Article
- HESX1- and TCF3-mediated repression of Wnt/β-catenin targets is required for normal development of the anterior forebrain.Development (Cambridge, England) · 2011Article
- Beta-catenin stimulates pituitary stem cells to form aggressive tumors.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- GENETIC DISORDERS OF PITUITARY DEVELOPMENT IN PATIENTS WITH SHEEHAN'S SYNDROME.Acta endocrinologica (Bucharest, Romania : 2005)Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Pituitary hormone deficiency causes short stature in one in 4000 children born and can be caused by mutations in transcription factor genes, including HESX1, PROP1, and POU1F1. HESX1 interacts with a member of the groucho-related gene family, TLE1, through an engrailed homology domain and represses PROP1 activity. Mice with Prop1 deficiency exhibit failed differentiation of the POU1F1 lineage, resulting in lack of TSH, GH, and prolactin. In addition, these mutants exhibit profound pituitary dysmorphology and excess Hesx1 and Tle3 expression. The ability of HESX1 to interact with TLE3 has not been explored previously. We tested the ability of TLE3 to enhance HESX1-mediated repression of PROP1 in cell culture. Both TLE3 and TLE1 repress PROP1 in conjunction with HESX1 with similar efficiencies. TLE1 and TLE3 can each repress PROP1 in the absence of HESX1 via a protein-protein interaction. We tested the functional consequences of ectopic TLE3 and HESX1 expression in transgenic mice by driving constitutive expression in pituitary thyrotrophs and gonadotrophs. Terminal differentiation of these cells was suppressed by HESX1 alone and by TLE3 and HESX1 together but not by TLE3 alone. In summary, we present evidence that HESX1 is a strong repressor that can be augmented by the corepressors TLE1 and TLE3. Our in vitro studies suggest that TLE1 and TLE3 might also play roles independent of HESX1 by interacting with other transcription factors like PROP1.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.