ArticleJournal of virology2010
Identification of a dominant negative inhibitor of human zinc finger antiviral protein reveals a functional endogenous pool and critical homotypic interactions.
Article in Journal of virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- Versatility of the Zinc-Finger Antiviral Protein (ZAP) As a Modulator of Viral Infections.International journal of biological sciences · 2024Review
- Antiviral Activity of Zinc Finger Antiviral Protein (ZAP) in Different Virus Families.Pathogens (Basel, Switzerland) · 2023Review
- Article
- Riplet Binds the Zinc Finger Antiviral Protein (ZAP) and Augments ZAP-Mediated Restriction of HIV-1.Journal of virology · 2022Article
- Comparison of CpG- and UpA-mediated restriction of RNA virus replication in mammalian and avian cells and investigation of potential ZAP-mediated shaping of host transcriptome compositions.RNA (New York, N.Y.) · 2022Article
- S-farnesylation is essential for antiviral activity of the long ZAP isoform against RNA viruses with diverse replication strategies.PLoS pathogens · 2021Article
- CpG Dinucleotides Inhibit HIV-1 Replication through Zinc Finger Antiviral Protein (ZAP)-Dependent and -Independent Mechanisms.Journal of virology · 2020Article
- Structure of the zinc-finger antiviral protein in complex with RNA reveals a mechanism for selective targeting of CG-rich viral sequences.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Characterization of Novel Splice Variants of Zinc Finger Antiviral Protein (ZAP).Journal of virology · 2019Article
- ZAP's stress granule localization is correlated with its antiviral activity and induced by virus replication.PLoS pathogens · 2019Article
- TRIM25 Enhances the Antiviral Action of Zinc-Finger Antiviral Protein (ZAP).PLoS pathogens · 2017Article
- Nuclear matrix protein Matrin 3 is a regulator of ZAP-mediated retroviral restriction.Retrovirology · 2015Article
- Poly(ADP-ribose) polymerase-13 and RNA regulation in immunity and cancer.Trends in molecular medicine · 2015Review
- Prenylome profiling reveals S-farnesylation is crucial for membrane targeting and antiviral activity of ZAP long-isoform.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Inhibition of hepatitis B virus replication by the host zinc finger antiviral protein.PLoS pathogens · 2013Article
- Translational repression precedes and is required for ZAP-mediated mRNA decay.The EMBO journal · 2012Article
- Structure of N-terminal domain of ZAP indicates how a zinc-finger protein recognizes complex RNA.Nature structural & molecular biology · 2012Article
- Multiple interferon stimulated genes synergize with the zinc finger antiviral protein to mediate anti-alphavirus activity.PloS one · 2012Article
- Strategies for viral RNA stability: live long and prosper.Trends in genetics : TIG · 2011Review
- Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm.Molecular cell · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The zinc finger antiviral protein (ZAP) is a host factor with potent antiviral activity when overexpressed in cells. ZAP blocks replication of the prototype alphavirus Sindbis virus (SINV) at a step at or before translation of the incoming viral genome. The mechanism of ZAP anti-SINV activity and the determinants of its antiviral function, however, have not been defined. Here, we have identified a dominant negative inhibitor of human ZAP. Rat ZAP with a cysteine-to-arginine mutation at position 88 (rZAPC88R), previously reported as a nonfunctional form of ZAP, increases SINV growth in cells. These results led us to discover a previously undetectable pool of endogenous functional ZAP within human cells. Investigation of the mechanism of dominant negative inhibition, combined with a comprehensive mutational analysis of the antiviral factor, revealed that homotypic associations are required for ZAP function in limiting SINV propagation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.