ArticleCerebral cortex (New York, N.Y. : 1991)2010
Unique contributions of distinct cholinergic projections to motor cortical plasticity and learning.
Article in Cerebral cortex (New York, N.Y. : 1991), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Right vagus nerve stimulation promotes motor cortical plasticity.Scientific reports · 2026Article
- Reciprocal molecular and cellular cholinergic working memory impairments in Alzheimer's disease model mice.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Cholinergic signaling differentially regulates a vocal motor pallial nucleus to stabilize adult birdsong.Communications biology · 2026Article
- Cell-type-specific cholinergic control of granular retrosplenial cortex with implications for angular velocity coding across brain states.Progress in neurobiology · 2025Article
- Article
- Neural mechanisms responsible for vagus nerve stimulation-dependent enhancement of somatosensory recovery.Scientific reports · 2024Article
- Vagus nerve stimulation during training fails to improve learning in healthy rats.Scientific reports · 2024Article
- Functional architecture of the forebrain cholinergic system in rodents.Research square · 2024Article
- Selective plasticity of layer 2/3 inputs onto distal forelimb controlling layer 5 corticospinal neurons with skilled grasp motor training.Cell reports · 2024Article
- Frequency Specific Optogenetic Stimulation of the Locus Coeruleus Induces Task-Relevant Plasticity in the Motor Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Multiscale model of primary motor cortex circuits predicts in vivo cell-type-specific, behavioral state-dependent dynamics.Cell reports · 2023Article
- The Anterior Cingulate Cortex Promotes Long-Term Auditory Cortical Responses through an Indirect Pathway via the Rhinal Cortex in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- taVNS Alleviates Sevoflurane-Induced Cognitive Dysfunction in Aged Rats Via Activating Basal Forebrain Cholinergic Neurons.Neurochemical research · 2023Article
- Vagus nerve stimulation drives selective circuit modulation through cholinergic reinforcement.Neuron · 2022Article
- The importance of volitional behavior in neuroplasticity.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Movement-dependent electrical stimulation for volitional strengthening of cortical connections in behaving monkeys.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The Response Dynamics and Function of Cholinergic and GABAergic Neurons in the Basal Forebrain During Olfactory Learning.Frontiers in cellular neuroscience · 2022Article
- Basal Forebrain Cholinergic Neurons Selectively Drive Coordinated Motor Learning in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Local activation of α2 adrenergic receptors is required for vagus nerve stimulation induced motor cortical plasticity.Scientific reports · 2021Article
- Cholinergic modulation of sensory processing in awake mouse cortex.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The cholinergic basal forebrain projects throughout the neocortex, exerting a critical role in modulating plasticity associated with normal learning. Cholinergic modulation of cortical plasticity could arise from 3 distinct mechanisms by 1) "direct" modulation via cholinergic inputs to regions undergoing plasticity, 2) "indirect" modulation via cholinergic projections to anterior, prefrontal attentional systems, or 3) modulating more global aspects of processing via distributed inputs throughout the cortex. To segregate these potential mechanisms, we investigated cholinergic-dependent reorganization of cortical motor representations in rats undergoing skilled motor learning. Behavioral and electrophysiological consequences of depleting cholinergic inputs to either motor cortex, prefrontal cortex, or globally, were compared. We find that local depletion of cholinergic afferents to motor cortex significantly disrupts map plasticity and skilled motor behavior, whereas prefrontal cholinergic depletion has no effect on these measures. Global cholinergic depletion perturbs map plasticity comparable with motor cortex depletions but results in significantly greater impairments in skilled motor acquisition. These findings indicate that local cholinergic activation within motor cortex, as opposed to indirect regulation of prefrontal systems, modulate cortical map plasticity and motor learning. More globally acting cholinergic mechanisms provide additional support for the acquisition of skilled motor behaviors, beyond those associated with cortical map reorganization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.