ArticleBiology of reproduction2010
EPAS1 Is Required for Spermatogenesis in the Postnatal Mouse Testis.
Article in Biology of reproduction, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Advances in the Molecular Regulatory Mechanisms of Testicular Development and Spermatogenesis in Yaks.Animals : an open access journal from MDPI · 2026Review
- Pathophysiological effects of hypoxia on testis function and spermatogenesis.Nature reviews. Urology · 2025Review
- Molecular insights into Sertoli cell function: how do metabolic disorders in childhood and adolescence affect spermatogonial fate?Nature communications · 2024Review
- The hypoxia-inducible factor EPAS1 is required for spermatogonial stem cell function in regenerative conditions.iScience · 2023Article
- Review
- Combined analysis of mRNA-miRNA from testis tissue in Tibetan sheep with different FecB genotypes.Open life sciences · 2023Article
- Impact of the hypoxic microenvironment on spermatogonial stem cells in culture.Frontiers in cell and developmental biology · 2023Article
- Conditional Deletion of HIF-2α in Mouse Nucleus Pulposus Reduces Fibrosis and Provides Mild and Transient Protection From Age-Dependent Structural Changes in Intervertebral Disc.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Follicle-stimulating hormone signaling in Sertoli cells: a licence to the early stages of spermatogenesis.Reproductive biology and endocrinology : RB&E · 2022Review
- Heat shock protein-90alpha (Hsp90α) stabilizes hypoxia-inducible factor-1α (HIF-1α) in support of spermatogenesis and tumorigenesis.Cancer gene therapy · 2021Article
- An interplay of NOX1-derived ROS and oxygen determines the spermatogonial stem cell self-renewal efficiency under hypoxia.Genes & development · 2021Article
- Effect of low oxygen tension on transcriptional factor OCT4 and SOX2 expression in New Zealand rabbit bone marrow-derived mesenchymal stem cells.Veterinary world · 2020Article
- Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS.Nature communications · 2020Article
- CBX2-dependent transcriptional landscape: implications for human sex development and its defects.Scientific reports · 2019Article
- Aberrant gene expression by Sertoli cells in infertile men with Sertoli cell-only syndrome.PloS one · 2019Article
- Research resource: the dynamic transcriptional profile of sertoli cells during the progression of spermatogenesis.Molecular endocrinology (Baltimore, Md.) · 2015Article
- Endothelial PAS domain-containing protein 1 confers TKI-resistance by mediating EGFR and MET pathways in non-small cell lung cancer cells.Cancer biology & therapy · 2015Article
- Hypoxia and spermatogenesis.International urology and nephrology · 2014Review
- Glycomimetic affinity-enrichment proteomics identifies partners for a clinically-utilized iminosugar.Chemical science · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Spermatogenesis, a process involving the differentiation of spermatogonial stem cells into mature spermatozoa, takes place throughout masculine life. A complex system in the testis, including endocrine signaling, physical interactions between germ and somatic cells, spermatocyte meiosis, and timely release of spermatozoa, controls this cycle. We demonstrate herein that decreased O(2) levels and Epas1 activation are critical components of spermatogenesis. Postnatal Epas1 ablation leads to male infertility, with reduced testis size and weight. While immature spermatogonia and spermatocytes are present in Epas1(Delta/Delta) testes, spermatid and spermatozoan numbers are dramatically reduced. This is not due to germ cell-intrinsic defects. Rather, Epas(Delta/Delta) Sertoli cells exhibit decreased ability to form tight junctions, thereby disrupting the blood-testis barrier necessary for proper spermatogenesis. Reduced numbers of tight junction complexes are due to decreased expression of multiple genes encoding tight junction proteins, including TJP1 (ZO1), TJP2 (ZO2), and occludin. Furthermore, Epas1(Delta/Delta) testes exhibit disrupted basement membranes surrounding the seminiferous tubules, causing the premature release of incompletely differentiated germ cells. We conclude that low O(2) levels in the male gonad regulate germ cell homeostasis in this organ via EPAS1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.