ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Homer 1a gates the induction mechanism for endocannabinoid-mediated synaptic plasticity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 52 citations in OpenAlex.
- Stearoyl-CoA Desaturase inhibition reverses immune, synaptic and cognitive impairments in an Alzheimer's disease mouse model.Nature communications · 2022Article
- Metaplasticity at the addicted tetrapartite synapse: A common denominator of drug induced adaptations and potential treatment target for addiction.Neurobiology of learning and memory · 2018Review
- Histone Deacetylase 2 Inhibition Attenuates Downregulation of Hippocampal Plasticity Gene Expression during Aging.Molecular neurobiology · 2018Article
- Immediate Early Genes, Memory and Psychiatric Disorders: Focus on c-Fos, Egr1 and Arc.Frontiers in behavioral neuroscience · 2018Review
- Monoacylglycerol lipase inhibitor JZL184 prevents HIV-1 gp120-induced synapse loss by altering endocannabinoid signaling.Neuropharmacology · 2018Article
- The DLGAP family: neuronal expression, function and role in brain disorders.Molecular brain · 2017Review
- BDNF-induced endocannabinoid release modulates neocortical glutamatergic neurotransmission.Synapse (New York, N.Y.) · 2017Article
- Dynamic Regulation of Homer Binding to Group I Metabotropic Glutamate Receptors by Preso1 and Converging Kinase Cascades.The Journal of pharmacology and experimental therapeutics · 2017Article
- Mechanisms of radiotherapy-associated cognitive disability in patients with brain tumours.Nature reviews. Neurology · 2017Review
- Scaffolding protein Homer1a protects against NMDA-induced neuronal injury.Cell death & disease · 2015Article
- Homer protein-metabotropic glutamate receptor binding regulates endocannabinoid signaling and affects hyperexcitability in a mouse model of fragile X syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Role for Endogenous BDNF in Endocannabinoid-Mediated Long-Term Depression at Neocortical Inhibitory SynapseseNeuro · 2015Article
- The Endocannabinoid Signaling System in the CNS: A Primer.International review of neurobiology · 2015Review
- Role of Immediate-Early Genes in Synaptic Plasticity and Neuronal Ensembles Underlying the Memory Trace.Frontiers in molecular neuroscience · 2015Review
- Impact of breathing 100% oxygen on radiation-induced cognitive impairment.Radiation research · 2014Article
- Dysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with Intellectual Disability and Autism.Neuroscience and biobehavioral reviews · 2014Review
- Parsing the players: 2-arachidonoylglycerol synthesis and degradation in the CNS.British journal of pharmacology · 2014Review
- Differential expression of Homer1a in the hippocampus and cortex likely plays a role in radiation-induced brain injury.Radiation research · 2014Article
- Endocannabinoid-dependent long-term depression in a nociceptive synapse requires coordinated presynaptic and postsynaptic transcription and translation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Epileptiform stimulus increases Homer 1a expression to modulate synapse number and activity in hippocampal cultures.Journal of neurophysiology · 2013Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
At hippocampal excitatory synapses, endocannabinoids (eCBs) mediate two forms of retrograde synaptic inhibition that are induced by postsynaptic depolarization or activation of metabotropic glutamate receptors (mGluRs). The homer family of molecular scaffolds provides spatial organization to regulate postsynaptic signaling cascades, including those activated by mGluRs. Expression of the homer 1a (H1a) immediate-early gene produces a short homer protein that lacks the domain required for homer oligomerization, enabling it to uncouple homer assemblies. Here, we report that H1a differentially modulates two forms of eCB-mediated synaptic plasticity, depolarization-induced suppression of excitation (DSE) and metabotropic suppression of excitation (MSE). EPSCs were recorded from cultured hippocampal neurons and DSE evoked by a 15 s depolarization to 0 mV and MSE evoked by a type I mGluR agonist. Expression of H1a enhanced DSE and inhibited MSE at the same synapse. Many physiologically important stimuli initiate H1a expression including brain-derived neurotrophic factor (BDNF). Treating hippocampal cultures with BDNF increased transcription of H1a and uncoupled homer 1c-GFP (green fluorescent protein) clusters. BDNF treatment blocked MSE and enhanced DSE. Thus, physiological changes in H1a expression gate the induction pathway for eCB-mediated synaptic plasticity by uncoupling mGluR from eCB production.
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Registered trials
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