ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Dopamine-dependent tuning of striatal inhibitory synaptogenesis.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Altered GABAergic Homeostasis in the Striatum of Dopamine Transporter Knockout Rats.Current neuropharmacology · 2025Article
- Image Analysis Routines for Quantification of Synaptic Density and Connectivity.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Magnetic Resonance Imaging Biomarkers of Punding in Parkinson's Disease.Brain sciences · 2023Article
- From Progenitors to Progeny: Shaping Striatal Circuit Development and Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Characterization of the Functional Cross-Talk between Surface GABAInternational journal of molecular sciences · 2021Article
- Diversity in striatal synaptic circuits arises from distinct embryonic progenitor pools in the ventral telencephalon.Cell reports · 2021Article
- The voltage-gated potassium channel Shaker promotes sleep via thermosensitive GABA transmission.Communications biology · 2020Article
- Presynaptic αThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Alteration of GABAergic neurotransmission in Huntington's disease.CNS neuroscience & therapeutics · 2018Review
- Differential Alteration in Expression of Striatal GABAFrontiers in molecular neuroscience · 2017Article
- γ-Aminobutyric Acid Type A (GABAA) Receptor Subunits Play a Direct Structural Role in Synaptic Contact Formation via Their N-terminal Extracellular Domains.The Journal of biological chemistry · 2016Article
- Metformin Prevented Dopaminergic Neurotoxicity Induced by 3,4-Methylenedioxymethamphetamine Administration.Neurotoxicity research · 2016Article
- The presence of cortical neurons in striatal-cortical co-cultures alters the effects of dopamine and BDNF on medium spiny neuron dendritic development.Frontiers in cellular neuroscience · 2015Article
- Regulation of GABAARs by phosphorylation.Advances in pharmacology (San Diego, Calif.) · 2015Review
- GABAA receptor activity shapes the formation of inhibitory synapses between developing medium spiny neurons.Frontiers in cellular neuroscience · 2015Article
- Pro-brain-derived neurotrophic factor inhibits GABAergic neurotransmission by activating endocytosis and repression of GABAA receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- MDMA administration during adolescence exacerbates MPTP-induced cognitive impairment and neuroinflammation in the hippocampus and prefrontal cortex.Psychopharmacology · 2014Article
- Characterization of a mammalian prosencephalic functional plan.Frontiers in neuroanatomy · 2014Review
- Inhibitory collaterals in genetically identified medium spiny neurons in mouse primary corticostriatal cultures.Physiological reports · 2013Article
- GABA(A) receptors can initiate the formation of functional inhibitory GABAergic synapses.The European journal of neuroscience · 2013Article
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8 authors.
Funding
Abstract
Dopaminergic projections to the striatum, crucial for the correct functioning of this brain region in adulthood, are known to be established early in development, but their role is currently uncharacterized. We demonstrate here that dopamine, by activating D(1)- and/or D(2)-dopamine receptors, decreases the number of functional GABAergic synapses formed between the embryonic precursors of the medium spiny neurons, the principal output neurons of the striatum, with associated changes in spontaneous synaptic activity. Activation of these receptors reduces the size of postsynaptic GABA(A) receptor clusters and their overall cell-surface expression, without affecting the total number of clusters or the size or number of GABAergic nerve terminals. These changes result from an increased internalization of GABA(A) receptors, and are mediated by distinct signaling pathways converging at the level of GABA(A) receptors to cause a transient PP2A/PP1-dependent dephosphorylation. Thus, tonic D(1)- and D(2)-receptor activity limits the extent of collateral inhibitory synaptogenesis between medium spiny neurons, revealing a novel role of dopamine in controlling the development of intrinsic striatal microcircuits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.