ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Inactivation of the central but not the basolateral nucleus of the amygdala disrupts learning in response to overexpectation of reward.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Probability and rate of reinforcement in negative prediction error learning.Journal of experimental psychology. Animal learning and cognition · 2025Article
- Alpha-2 agonism in the locus coeruleus impairs learning driven by negative prediction error.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- The role of the mediodorsal thalamus in chemosensory preference and consummatory behavior in rats.Chemical senses · 2024Article
- Engaging endogenous opioid circuits in pain affective processes.Journal of neuroscience research · 2022Review
- Acute Hypophagia and Changes in c-Fos Immunoreactivity in Adolescent Rats Treated with Low Doses of Oxytocin and Naltrexone.Journal of clinical medicine · 2021Article
- Choose your path: Divergent basolateral amygdala efferents differentially mediate incentive motivation, flexibility and decision-making.Behavioural brain research · 2021Review
- Consolidation of altered associability information by amygdala central nucleus.Neurobiology of learning and memory · 2016Article
- Neural correlates of two different types of extinction learning in the amygdala central nucleus.Nature communications · 2016Article
- Effects of amygdala lesions on overexpectation phenomena in food cup approach and autoshaping procedures.Behavioral neuroscience · 2016Article
- Mini-review: Prediction errors, attention and associative learning.Neurobiology of learning and memory · 2016Review
- Neurophysiology of Reward-Guided Behavior: Correlates Related to Predictions, Value, Motivation, Errors, Attention, and Action.Current topics in behavioral neurosciences · 2016Review
- Neural Estimates of Imagined Outcomes in Basolateral Amygdala Depend on Orbitofrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The Origins and Organization of Vertebrate Pavlovian Conditioning.Cold Spring Harbor perspectives in biology · 2015Review
- Effects of prior cocaine versus morphine or heroin self-administration on extinction learning driven by overexpectation versus omission of reward.Biological psychiatry · 2015Article
- Learning theory: a driving force in understanding orbitofrontal function.Neurobiology of learning and memory · 2014Review
- Neural estimates of imagined outcomes in the orbitofrontal cortex drive behavior and learning.Neuron · 2013Article
- Neural correlates of Pavlovian-to-instrumental transfer in the nucleus accumbens shell are selectively potentiated following cocaine self-administration.The European journal of neuroscience · 2011Article
- The central amygdala projection to the substantia nigra reflects prediction error information in appetitive conditioning.Learning & memory (Cold Spring Harbor, N.Y.) · 2010Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The amygdala is critical for associating predictive cues with primary rewarding and aversive outcomes. This is particularly evident in tasks in which information about expected outcomes is required for normal responding. Here we used a pavlovian overexpectation task to test whether outcome signaling by amygdala might also be necessary for changing those representations in the face of unexpected outcomes. Rats were trained to associate several different cues with a food reward. After learning, two of the cues were presented together, in compound, followed by the same reward. Before each compound training session, rats received infusions of 2,3-dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide or saline into either the basolateral (ABL) or central nucleus (CeN) of amygdala. We found that infusions into CeN abolished the normal decline in responding to the compounded cue in a later probe test, whereas infusions into ABL had no effect. These results are inconsistent with the proposal that signaling of information about expected outcomes by ABL contributes to learning, at least in this setting, and instead implicate the CeN in this process, perhaps attributable to the hypothesized involvement of this area in attention and variations in stimulus processing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.