ArticleRespiratory research2010
Inhaled salmeterol and/or fluticasone alters structure/function in a murine model of allergic airways disease.
Article in Respiratory research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed.
- Use of a novel one-nostril mask-spacer device to evaluate airway hyperresponsiveness (AHR) in horses after chronic administration of albuterol.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2014Trial
- Fluticasone Propionate/Anti-IgE Combination Preserves Bone Mechanical and Mineral Integrity Better than Monotherapies or Anti-TNF-α in Mice with Ovalbumin-Induced Allergic Airway Inflammation.International journal of molecular sciences · 2026Article
- Epithelial Barrier Dysfunction in Chronic Respiratory Diseases.Frontiers in physiology · 2021Review
- Inhaled corticosteroids as treatment for adolescent asthma: effects on adult anxiety-related outcomes in a murine model.Psychopharmacology · 2021Article
- Paradoxical Bronchoconstriction with Short-Acting Beta Agonist.The American journal of case reports · 2018Article
- Airway Mucus and Asthma: The Role of MUC5AC and MUC5B.Journal of clinical medicine · 2017Review
- βProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Fluticasone/salmeterol reduces remodelling and neutrophilic inflammation in severe equine asthma.Scientific reports · 2017Article
- Co-inhalation of roflumilast, rather than formoterol, with fluticasone more effectively improves asthma in asthmatic mice.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Magnetic Nanodrug Delivery Through the Mucus Layer of Air-Liquid Interface Cultured Primary Normal Human Tracheobronchial Epithelial Cells.BioNanoScience · 2016Article
- Phosphodiesterase 4 Inhibitors Attenuate the Asthma Phenotype Produced by β2-Adrenoceptor Agonists in Phenylethanolamine N-Methyltransferase-Knockout Mice.American journal of respiratory cell and molecular biology · 2016Article
- Long-Acting Beta Agonists Enhance Allergic Airway Disease.PloS one · 2015Article
- Role for β-arrestin in mediating paradoxical β2AR and PAR2 signaling in asthma.Current opinion in pharmacology · 2014Review
- Article
- Effect of fluticasone and salmeterol on tracheal responsiveness to ovalbumin and lung inflammation, administrated during and after sensitization.TheScientificWorldJournal · 2014Article
- Endoplasmic reticulum stress mediates house dust mite-induced airway epithelial apoptosis and fibrosis.Respiratory research · 2013Article
- Noninvasive intratracheal intubation to study the pathology and physiology of mouse lung.Journal of visualized experiments : JoVE · 2013Article
- Genetic ablation of glutaredoxin-1 causes enhanced resolution of airways hyperresponsiveness and mucus metaplasia in mice with allergic airways disease.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Respiratory health of elite athletes - preventing airway injury: a critical review.British journal of sports medicine · 2012Review
- Chronic treatment in vivo with β-adrenoceptor agonists induces dysfunction of airway β(2) -adrenoceptors and exacerbates lung inflammation in mice.British journal of pharmacology · 2012Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundThe relationship between airway structural changes (remodeling) and airways hyperresponsiveness (AHR) is unclear. Asthma guidelines suggest treating persistent asthma with inhaled corticosteroids and long acting beta-agonists (LABA). We examined the link between physiological function and structural changes following treatment fluticasone and salmeterol separately or in combination in a mouse model of allergic asthma.
methodsBALB/c mice were sensitized to intraperitoneal ovalbumin (OVA) followed by six daily inhalation exposures. Treatments included 9 daily nebulized administrations of fluticasone alone (6 mg/ml), salmeterol (3 mg/ml), or the combination fluticasone and salmeterol. Lung impedance was measured following methacholine inhalation challenge. Airway inflammation, epithelial injury, mucus containing cells, and collagen content were assessed 48 hours after OVA challenge. Lungs were imaged using micro-CT. RESULTS AND DISCUSSION: Treatment of allergic airways disease with fluticasone alone or in combination with salmeterol reduced AHR to approximately naüve levels while salmeterol alone increased elastance by 39% compared to control. Fluticasone alone and fluticasone in combination with salmeterol both reduced inflammation to near naive levels. Mucin containing cells were also reduced with fluticasone and fluticasone in combination with salmeterol.
conclusionsFluticasone alone and in combination with salmeterol reduces airway inflammation and remodeling, but salmeterol alone worsens AHR: and these functional changes are consistent with the concomitant changes in mucus metaplasia.
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