ArticleBMC evolutionary biology2010
Exploring the evolutionary dynamics of plasmids: the Acinetobacter pan-plasmidome.
Article in BMC evolutionary biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed, 90 citations in OpenAlex.
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- Carbapenem-resistant bacteria in the environment.Arhiv za higijenu rada i toksikologiju · 2025Review
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- A global survey ofMicrobial genomics · 2023Article
- Metagenomic analysis reveals gut plasmids as diagnosis markers for colorectal cancer.Frontiers in microbiology · 2023Article
- Plasmids as Key Players inInternational journal of molecular sciences · 2022Review
- Analysis of pCl107 a large plasmid carried by an ST25FEMS microbes · 2022Article
- The Spread of Antibiotic Resistance Genes In Vivo Model.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022Review
- Analysis of chronic inflammatory lesions of the colon for BMMF Rep antigen expression and CD68 macrophage interactions.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- What do we know about plasmids carried by members of the Acinetobacter genus?World journal of microbiology & biotechnology · 2020Review
- Prevalence and Characterization of Carbapenem-Hydrolyzing Class D β-Lactamase-ProducingFrontiers in microbiology · 2020Article
- A Novel Family ofFrontiers in microbiology · 2020Article
- Structure and Evolution ofFrontiers in microbiology · 2020Article
- Assessing genetic diversity and similarity of 435 KPC-carrying plasmids.Scientific reports · 2019Article
- Characterization of the diverse plasmid pool harbored by the blaNDM-1-containing Acinetobacter bereziniae HPC229 clinical strain.PloS one · 2019Article
- High DNA Uptake Capacity of International Clone IIFrontiers in microbiology · 2019Article
- A specific class of infectious agents isolated from bovine serum and dairy products and peritumoral colon cancer tissue.Emerging microbes & infections · 2019Article
- PlasFlow: predicting plasmid sequences in metagenomic data using genome signatures.Nucleic acids research · 2018Article
- Site-Specific Recombination at XerC/D Sites Mediates the Formation and Resolution of Plasmid Co-integrates Carrying aFrontiers in microbiology · 2018Article
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Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProkaryotic plasmids have a dual importance in the microbial world: first they have a great impact on the metabolic functions of the host cell, providing additional traits that can be accumulated in the cell without altering the gene content of the bacterial chromosome. Additionally and/or alternatively, from a genome perspective, plasmids can provide a basis for genomic rearrangements via homologous recombination and so they can facilitate the loss or acquisition of genes during these events, which eventually may lead to horizontal gene transfer (HGT). Given their importance for conferring adaptive traits to the host organisms, the interest in plasmid sequencing is growing and now many complete plasmid sequences are available online.
resultsBy using the newly developed Blast2Network bioinformatic tool, a comparative analysis was performed on the plasmid and chromosome sequence data available for bacteria belonging to the genus Acinetobacter, an ubiquitous and clinically important group of gamma-proteobacteria. Data obtained showed that, although most of the plasmids lack mobilization and transfer functions, they have probably a long history of rearrangements with other plasmids and with chromosomes. Indeed, traces of transfers between different species can be disclosed.
conclusionsWe show that, by combining plasmid and chromosome similarity, identity based, network analysis, an evolutionary scenario can be described even for highly mobile genetic elements that lack extensively shared genes. In particular we found that transposases and selective pressure for mercury resistance seem to have played a pivotal role in plasmid evolution in Acinetobacter genomes sequenced so far.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.