ArticleBMC biology2010
The IGF1 small dog haplotype is derived from Middle Eastern grey wolves.
Article in BMC biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers.
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35 citing papers in PubMed, 74 citations in OpenAlex.
- Natural and human-driven selection of a single non-coding body size variant in ancient and modern canids.Current biology : CB · 2022Article
- A synonymous mutation inMolecular therapy. Nucleic acids · 2021Article
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- SINE Insertion in the Intron of PigAnimals : an open access journal from MDPI · 2021Article
- Long-read assembly of a Great Dane genome highlights the contribution of GC-rich sequence and mobile elements to canine genomes.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Review
- Transposon activation is a major driver in the genome evolution of cultivated olive trees (Olea europaea L.).The plant genome · 2020Article
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- Evolutionary dynamics of transposable elements during silkworm domestication.Genes & genomics · 2018Article
- Natural Selection and Origin of a Melanistic Allele in North American Gray Wolves.Molecular biology and evolution · 2018Article
- Article
- Genetic diversity and population structure of African village dogs based on microsatellite and immunity-related molecular markers.PloS one · 2018Article
- Structural variants in genes associated with human Williams-Beuren syndrome underlie stereotypical hypersociability in domestic dogs.Science advances · 2017Article
- The concerted impact of domestication and transposon insertions on methylation patterns between dogs and grey wolves.Molecular ecology · 2016Article
- Evaluating the performance of selection scans to detect selective sweeps in domestic dogs.Molecular ecology · 2016Article
- Homeodomain Protein Scr Regulates the Transcription of Genes Involved in Juvenile Hormone Biosynthesis in the Silkworm.International journal of molecular sciences · 2015Article
- Ancient DNA analysis of the oldest canid species from the Siberian Arctic and genetic contribution to the domestic dog.PloS one · 2015Article
- Establishing the validity of domestication genes using DNA from ancient chickens.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Genome-wide signatures of population bottlenecks and diversifying selection in European wolves.Heredity · 2014Article
- Derived variants at six genes explain nearly half of size reduction in dog breeds.Genome research · 2013Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundA selective sweep containing the insulin-like growth factor 1 (IGF1) gene is associated with size variation in domestic dogs. Intron 2 of IGF1 contains a SINE element and single nucleotide polymorphism (SNP) found in all small dog breeds that is almost entirely absent from large breeds. In this study, we surveyed a large sample of grey wolf populations to better understand the ancestral pattern of variation at IGF1 with a particular focus on the distribution of the small dog haplotype and its relationship to the origin of the dog.
resultsWe present DNA sequence data that confirms the absence of the derived small SNP allele in the intron 2 region of IGF1 in a large sample of grey wolves and further establishes the absence of a small dog associated SINE element in all wild canids and most large dog breeds. Grey wolf haplotypes from the Middle East have higher nucleotide diversity suggesting an origin there. Additionally, PCA and phylogenetic analyses suggests a closer kinship of the small domestic dog IGF1 haplotype with those from Middle Eastern grey wolves.
conclusionsThe absence of both the SINE element and SNP allele in grey wolves suggests that the mutation for small body size post-dates the domestication of dogs. However, because all small dogs possess these diagnostic mutations, the mutations likely arose early in the history of domestic dogs. Our results show that the small dog haplotype is closely related to those in Middle Eastern wolves and is consistent with an ancient origin of the small dog haplotype there. Thus, in concordance with past archeological studies, our molecular analysis is consistent with the early evolution of small size in dogs from the Middle East.See associated opinion by Driscoll and Macdonald: http://jbiol.com/content/9/2/10.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.