ArticleCell division2010
Self-organization of intracellular gradients during mitosis.
Article in Cell division, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Many will enter, few will win: Cost and sensitivity of exploratory dynamics.Biophysical journal · 2026Article
- Collective effects of cell cleavage dynamics.Frontiers in cell and developmental biology · 2024Review
- Modeling protein dynamics inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Rapid diffusion-state switching underlies stable cytoplasmic gradients in theProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Polo-like Kinase Couples Cytoplasmic Protein Gradients in the C. elegans Zygote.Current biology : CB · 2018Article
- DNA-relay mechanism is sufficient to explain ParA-dependent intracellular transport and patterning of single and multiple cargos.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The Slow Mobility of the ParA Partitioning Protein Underlies Its Steady-State Patterning in Caulobacter.Biophysical journal · 2016Article
- Origin of Cancer: An Information, Energy, and Matter Disease.Frontiers in cell and developmental biology · 2016Article
- Pom1 gradient buffering through intermolecular auto-phosphorylation.Molecular systems biology · 2015Article
- Regulatory mechanisms that control mitotic kinesins.Experimental cell research · 2015Review
- Pom1 regulates the assembly of Cdr2-Mid1 cortical nodes for robust spatial control of cytokinesis.The Journal of cell biology · 2014Article
- Emergent complexity of the cytoskeleton: from single filaments to tissue.Advances in physics · 2013Review
- Intrinsic microtubule GTP-cap dynamics in semi-confined systems: kinetochore-microtubule interface.Journal of biological physics · 2013Article
- Residual HIV-1 DNA Flap-independent nuclear import of cPPT/CTS double mutant viruses does not support spreading infection.Retrovirology · 2011Article
- Dynamic as well as stable protein interactions contribute to genome function and maintenance.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2011Article
- BIOMIMETIC GRADIENT HYDROGELS FOR TISSUE ENGINEERING.The Canadian journal of chemical engineering · 2010Article
- Revisiting HIV-1 uncoating.Retrovirology · 2010Review
- Modeling of spatially-restricted intracellular signaling.Wiley interdisciplinary reviews. Systems biology and medicineReview
- Regulation and coordination of nuclear envelope and nuclear pore complex assembly.Nucleus (Austin, Tex.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gradients are used in a number of biological systems to transmit spatial information over a range of distances. The best studied are morphogen gradients where information is transmitted over many cell lengths. Smaller mitotic gradients reflect the need to organize several distinct events along the length of the mitotic spindle. The intracellular gradients that characterize mitosis are emerging as important regulatory paradigms. Intracellular gradients utilize intrinsic auto-regulatory feedback loops and diffusion to establish stable regions of activity within the mitotic cytosol. We review three recently described intracellular mitotic gradients. The Ran GTP gradient with its elaborate cascade of nuclear transport receptors and cargoes is the best characterized, yet the dynamics underlying the robust gradient of Ran-GTP have received little attention. Gradients of phosphorylation have been observed on Aurora B kinase substrates both before and after anaphase onset. In both instances the phosphorylation gradient appears to result from a soluble gradient of Aurora B kinase activity. Regulatory properties that support gradient formation are highlighted. Intracellular activity gradients that regulate localized mitotic events bare several hallmarks of self-organizing biologic systems that designate spatial information during pattern formation. Intracellular pattern formation represents a new paradigm in mitotic regulation.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.