ArticleInternational archives of medicine2010
Cardiac baroreflex is already blunted in eight weeks old spontaneously hypertensive rats.
Article in International archives of medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Anti-hypertensive drugs have different effects on ventricular hypertrophy regression.Clinics (Sao Paulo, Brazil) · 2010Pooled it
- Neural Control of Tissue Perfusion: Emerging Evidence and Beyond.Current hypertension reports · 2026Review
- Cardiovascular responses induced by Catalase Inhibitior into the Fourth Cerebral Ventricle is changed in Wistar rats exposed to sidestream cigarette smoke.International journal of health sciences · 2013Article
- Effects of the administration of a catalase inhibitor into the fourth cerebral ventricle on cardiovascular responses in spontaneously hypertensive rats exposed to sidestream cigarette smoke.Clinics (Sao Paulo, Brazil) · 2013Article
- Sidestream cigarette smoke and cardiac autonomic regulation.International archives of medicine · 2013Article
- Neurogenic hypertension and elevated vertebrobasilar arterial resistance: is there a causative link?Current hypertension reports · 2012Review
- Time course of the hemodynamic responses to aortic depressor nerve stimulation in conscious spontaneously hypertensive rats.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2012Article
- Baroreflex sensitivity differs among same strain Wistar rats from the same laboratory.Heart international · 2011Article
- Protective effect of the daming capsule on impaired baroreflexes in STZ-induced diabetic rats with hyperlipoidemia.BMC complementary and alternative medicine · 2010Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe literature did not evidence yet with which age spontaneously hypertensive rats (SHR) start to present baroreflex reduction. We endeavored to evaluate the baroreflex function in eight-week-old SHR.
methodsMale Wistar Kyoto (WKY) normotensive rats and SHR aged eight weeks were studied. Baroreflex was calculated as the variation of heart rate (HR) divided by the mean arterial pressure (MAP) variation (DeltaHR/DeltaMAP) tested with a depressor dose of sodium nitroprusside (SNP, 50 microg/kg) and with a pressor dose of phenylephrine (PHE, 8 microg/kg) in the right femoral venous approach through an inserted cannula in the animals. Significant differences for p < 0.05.
resultsBaseline MAP (p < 0.0001) and HR (p = 0.0028) was higher in SHR. Bradycardic peak was attenuated in SHR (p < 0.0001), baroreflex gain tested with PHE was also reduced in the SHR group (p = 0.0012). PHE-induced increase in MAP was increased in WKY compared to SHR (p = 0.039). Bradycardic reflex responses to intravenous PHE was decreased in SHR (p < 0.0001).
conclusionEight weeks old SHR already presents impairment of the parasympathetic component of baroreflex.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.