ArticleJournal of circadian rhythms2010
CLOCK is suggested to associate with comorbid alcohol use and depressive disorders.
Article in Journal of circadian rhythms, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
46 citing papers in PubMed, 96 citations in OpenAlex.
- Timing matters: circadian rhythm disruption in alcohol-associated peripheral organ pathophysiology.Function (Oxford, England) · 2026Review
- The Beauty Sleep to Keep a Healthy Liver.International journal of molecular sciences · 2025Review
- Latent profile analysis of depressive symptoms in older patients with chronic diseases and their relationship with social support study.BMC psychology · 2025Article
- Translational implications of circadian activity alterations in an experimental model of late-onset depression induced by prenatal excess of glucocorticoids.Frontiers in behavioral neuroscience · 2025Review
- DAILY - A personalized circadianFrontiers in psychiatry · 2025Article
- Sex- and Substance-Specific Associations of Circadian-Related Genes with Addiction in the UK Biobank Cohort Implicate Neuroplasticity Pathways.Brain sciences · 2024Article
- Circadian Typology and Physical Activity in Young Adults with Gaming Disorder.Medicina (Kaunas, Lithuania) · 2024Article
- Disrupted Circadian Rhythms and Substance Use Disorders: A Narrative Review.Clocks & sleep · 2024Review
- A Complex Relationship Among the Circadian Rhythm, Reward Circuit and Substance Use Disorder (SUD).Psychology research and behavior management · 2024Review
- Role of polygenic risk scores in the association between chronotype and health risk behaviors.BMC psychiatry · 2023Article
- RETN gene polymorphisms interact with alcohol dependence in association with depression.Journal of clinical laboratory analysis · 2023Article
- Behavior change versus stability during the college-to-work transition: Life course and the "stickiness" of alcohol misuse at career entry.Personnel psychology · 2023Article
- Targeting the Maladaptive Effects of Binge Drinking on Circadian Gene Expression.International journal of molecular sciences · 2022Article
- Astrocyte Molecular Clock Function in the Nucleus Accumbens Is Important for Reward-Related Behavior.Biological psychiatry · 2022Article
- Patterns of activity correlate with symptom severity in major depressive disorder patients.Translational psychiatry · 2022Article
- Article
- Altered expression of somatostatin signaling molecules and clock genes in the hippocampus of subjects with substance use disorder.Frontiers in neuroscience · 2022Article
- Rhythms, Reward, and Blues: Consequences of Circadian Photoperiod on Affective and Reward Circuit Function.Neuroscience · 2021Review
- Every Night and Every Morn: Effect of Variation inFrontiers in psychiatry · 2021Article
- Association between Alcohol Drinking Status and Depressive Symptoms in Korean Adults.Chonnam medical journal · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDepression and alcohol abuse or dependence (AUD) co-occur in the general population more frequently than expected by chance. Alcohol use influences the circadian rhythms generated by the central pacemaker in the suprachiasmatic nucleus, and circadian rhythm alterations in turn are common in depressive disorders as well as among persons addicted to alcohol.
methods32 SNPs in 19 circadian clockwork related genes were analyzed using DNA from 76 individuals with comorbid depression and AUD, 446 individuals with AUD and 517 healthy controls with no psychiatric diagnosis. The individuals participated in a nationwide health examination study, representative of the general population aged 30 and over in Finland.
resultsThe CLOCK haplotype TTGC formed by SNPs rs3805151, rs2412648, rs11240 and rs2412646, was associated with increased risk for comorbidity (OR = 1.65, 95% CI = 1.14-2.28, P = 0.0077). The SNPs of importance for this suggestive association were rs2412646 and rs11240 indicating location of the functional variation in the block downstream rs2412648. There was no indication for association between CLOCK and AUD.
conclusionOur findings suggest an association between the CLOCK gene and the comorbid condition of alcohol use and depressive disorders. Together with previous reports it indicates that the CLOCK variations we found here may be a vulnerability factor to depression given the exposure to alcohol in individuals having AUD.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.