ArticleWorld journal of gastroenterology2010
Effects of anti-hypertensive drugs on esophageal body contraction.
Article in World journal of gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Effects of mosapride on esophageal motor activity and esophagogastric junction compliance in healthy volunteers.Journal of gastroenterology · 2014Trial
- Impact of nicotine product use on outcomes of patients receiving cervical disc arthroplasty: a propensity score analysis of the united States nationwide inpatient sample 2005-2020.Journal of orthopaedic surgery and research · 2025Article
- Genetic evidence for amlodipine's protective role in gastroesophageal reflux disease: A focus on CACNB2.PloS one · 2025Article
- Article
- Risk factors and impact of swallowing impairment and aspiration after lung transplantation.Journal of thoracic disease · 2024Article
- Investigating causal links between gastroesophageal reflux disease and essential hypertension.World journal of clinical cases · 2024Article
- Association of pneumonia admission with polypharmacy and drug use in community-dwelling older people.Geriatrics & gerontology international · 2024Article
- Efficacy of magnesium sulfate combined with nifedipine for pregnancy-induced hypertension syndrome and its relation to glucose and lipid metabolism.American journal of translational research · 2023Article
- Increased risk of reflux esophagitis in non-obese individuals with nonalcoholic fatty liver disease: a cross-sectional study.Annals of medicine · 2023Article
- Gender, medication use and other factors associated with esophageal motility disorders in non-obstructive dysphagia.Gastroenterology report · 2018Article
- Association of medications for lifestyle-related diseases with reflux esophagitis.Therapeutics and clinical risk management · 2016Article
- Association between metabolic syndrome and prevalence of gastroesophageal reflux disease in a health screening facility in Japan.Journal of gastroenterology · 2013Article
- Effects of Rikkunshito (TJ-43) on Esophageal Motor Function and Gastroesophageal Reflux.Journal of neurogastroenterology and motility · 2012Article
- Influence of Full-body Water Immersion on Esophageal Motor Function and Intragastric Pressure.Journal of neurogastroenterology and motility · 2012Article
- Calcium channel blockers and esophageal sclerosis: should we expect exacerbation of interstitial lung disease?Case reports in gastroenterology · 2012Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo clarify the effects of anti-hypertensive drugs on esophageal contraction and determine their possible relationship with gastro-esophageal reflux disease.
methodsThirteen healthy male volunteers were enrolled. Esophageal body peristaltic contractions and lower esophageal sphincter (LES) pressure were measured using high resolution manometry. All subjects were randomly examined on four separate occasions following administrations of nifedipine, losartan, and atenolol, as well as without any drug administration.
resultsPeristaltic contractions by the esophageal body were separated into three segments by two troughs. The peak peristaltic pressures in the mid and lower segments of the esophageal body under atenolol administration were significantly higher than those without medication in a supine position. On the other hand, peristaltic pressures under nifedipine administration were lower than those observed without drug administration. Losartan did not change esophageal body peristalsis. Atenolol elevated LES pressure and slowed peristaltic wave transition, while the effects of nifedipine were the opposite.
conclusionAmong the anti-hypertensive drugs tested, atenolol enhanced esophageal motor activity, which was in contrast to nifedipine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.