ArticleWorld journal of gastroenterology2010
Clinical and cost impact of intravenous proton pump inhibitor use in non-ICU patients.
Article in World journal of gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 56 citations in OpenAlex.
- Evaluation of Stress Ulcer Prophylaxis Use Among Adult Patients Admitted to the Intensive Care Unit in Northwest Ethiopia Hospitals During 2024: A Multicenter Cross-Sectional Study.Health science reports · 2026Article
- Impact of an IV proton pump inhibitor restriction policy on prescribing patterns and estimated drug cost.Frontiers in pharmacology · 2026Article
- Insights into stress ulcer prophylaxis among non-critically ill patients: a tertiary hospital perspective from Sudan.Journal of pharmaceutical health care and sciences · 2025Article
- Optimizing stress ulcer prophylaxis practices and reducing associated costs in intensive care units: a non-randomized controlled study.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2025Article
- Ensuring guideline adherence and cost savings in stress ulcer prophylaxis practices in the intensive care unit: a pre-post education study.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2025Article
- Predictive Factors Associated with Inappropriate Intravenous Proton Pump Inhibitors Use in Hospitalized Patients: A Case-Control Study.Medicina (Kaunas, Lithuania) · 2024Article
- Assessment of the appropriateness of stress ulcer prophylaxis use and its determinants among admitted surgical patients at Debre Berhan University Hakim Gizaw Hospital, Ethiopia. A hospital-based cross-sectional study.Frontiers in medicine · 2024Article
- Appropriateness and inappropriate medication predictors of stress ulcer prophylaxis in the intensive care unit.Frontiers in pharmacology · 2024Article
- Prospective prescription review system correlated with more rational PPI medication use, better clinical outcomes and reduced PPI costs: experience from a retrospective cohort study.BMC health services research · 2023Article
- Evaluation of Proton Pump Inhibitors Prescribing Among Hospitalized Patients: A Cross-Sectional Study.International journal of general medicine · 2023Article
- Appropriateness and Associated Factors of Stress Ulcer Prophylaxis for Surgical Inpatients of Orthopedics Department in a Tertiary Hospital: A Cross-Sectional Study.Frontiers in pharmacology · 2022Article
- A Cross-Sectional Study on Single-Day Use of Proton Pump Inhibitors in Tertiary Care Hospitals of South India.Hospital pharmacy · 2021Article
- Assessment of pharmacologic prophylaxis use against stress ulcer in the medical wards of University of Gondar Hospital.SAGE open medicine · 2019Article
- Variables Associated with Adherence to Stress Ulcer Prophylaxis in Patients Admitted to the General Hospital Wards: A Prospective Study.Advanced pharmaceutical bulletin · 2017Article
- The use of proton pump inhibitors in an Italian hospital: focus on oncologic and critical non-ICU patients.International journal of clinical pharmacy · 2015Observational
- Article
- Attitude and Knowledge of Indian Emergency Care Residents towards Use of Proton Pump Inhibitors.International scholarly research notices · 2014Article
- Variables associated with stress ulcer prophylaxis misuse: a retrospective analysis.Digestive diseases and sciences · 2012Article
- Adherence to stress-related mucosal damage prophylaxis guideline in patients admitted to the Intensive Care Unit.Journal of research in pharmacy practiceArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo assess the appropriateness of the indication and route of administration of proton-pump-inhibitors (PPIs) and their associated cost impact.
methodsData collection was performed prospectively during a 6-mo period on 340 patients who received omeprazole intravenously during their hospital stay in non-intensive care floors. Updated guidelines were used to assess the appropriateness of the indication and route of administration.
resultsComplete data collection was available for 286 patients which were used to assess intravenous (IV) PPIs utilization. Around 88% of patients were receiving PPIs for claimed stress ulcer prophylaxis (SUP) indication; of which, only 17% met the guideline criteria for SUP indication, 14% met the criteria for non-steroidal-anti-inflammatory drugs-induced ulcer prophylaxis, while the remaining 69% were identified as having an unjustified indication for PPI use. The initiation of IV PPIs was appropriate in 55% of patients. Half of these patients were candidates for switching to the oral dosage form during their hospitalization, while only 36.7% of these patients were actually switched. The inappropriate initiation of PPIs via the IV route was more likely to take place on the medical floor than the surgical floor (53% vs 36%, P = 0.003). The cost analysis associated with the appropriateness of the indication for PPI use as well as the route of administration of PPI revealed a possible saving of up to $17,732.5 and $14,571, respectively.
conclusionThis study highlights the over-utilization of IV PPIs in non-intensive care unit patients. Restriction of IV PPI use for justified indications and route of administration is recommended.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.