Evidence map›Paper›PMID 20180109›Full record

Trial reportPediatric radiology2010

Intranasal fentanyl versus placebo for pain in children during catheterization for voiding cystourethrography.

Seen Chung, Ruth Lim, Ran D Goldman

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Pediatric radiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00405444 (Intranasal Fentanyl Versus Placebo for Catheterization During a Voiding Cystourethrogram in Children), which is not on this map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
6.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00405444 phase3completednot on this map

Intranasal Fentanyl Versus Placebo for Catheterization During a Voiding Cystourethrogram in Children

TypeinterventionalSponsorThe Hospital for Sick ChildrenRan2006 to 2008Enrolled64ConditionsPainArmsFentanyl, Sterile water
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Intranasal fentanyl for the management of acute pain in children.The Cochrane database of systematic reviews · 2014
    Pooled it
  2. Pooled it
  3. Trial
  4. Intranasal sumatriptan for migraine in children.Canadian family physician Medecin de famille canadien · 2015
    Article
  5. Long-term efficacy and tolerability of intranasal fentanyl in the treatment of breakthrough cancer pain.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2015
    Observational
  6. Non-Intravenous Sedatives and Analgesics for Procedural Sedation for Imaging Procedures in Pediatric Patients.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
    Review
  7. Sedation and Analgesia Using Medications Delivered via the Extravascular Route in Children Undergoing Laceration Repair.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Seen ChungDivision of Pediatric Emergency Medicine, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON, Canada.
Ruth Lim
Ran D Goldman
Harvard University · USHospital for Sick Children · CAUniversity of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVoiding cystourethrogram (VCUG) is a common procedure at pediatric tertiary care centres that can be painful as it involves a urinary catheter. Currently there are no widely utilized protocols for non-topical medications to decrease pain that children feel during catheterization.

objectiveTo determine if intranasal (IN) fentanyl is effective at decreasing pain that children feel during catheterization of VCUG when compared with sterile water. MATERIALS AND

methodsWe performed a double-blind randomized controlled trial, using IN fentanyl (2 microg/kg) compared to placebo (sterile water,) in children 4-8 years of age scheduled for elective VCUG in one urban pediatric tertiary center.

resultsUsing the Face Pain Score-Revised, children receiving IN fentanyl scored 2.58 (1.93-3.25 95% CI) while those receiving sterile water scored 2.86 (2.20-3.51 95% CI) showing no statistically significant difference. There were no adverse events.

conclusionsAlthough we were unable to show a statistically significant difference between our study and control groups, we believe that this may be due to technique (positioning, delivery device) and timing of administration of IN fentanyl as well as multi-factorial causes of distress during VCUG. Future studies investigating alternative delivery techniques of IN fentanyl for analgesia during VCUG may yield more promising results.

Indexed as

Administration, IntranasalAnalgesics, OpioidChildChild, PreschoolDouble-Blind MethodFemaleFentanylHumansMalePainPain MeasurementPlacebo EffectTreatment OutcomeUrinary CatheterizationUrinationUrographyAnalgesics, OpioidFentanyl

Identifiers

PMID20180109
OpenAlexW1996249777

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.