ArticleCalcified tissue international2010
A mineral-rich extract from the red marine algae Lithothamnion calcareum preserves bone structure and function in female mice on a Western-style diet.
Article in Calcified tissue international, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02647671 (The Effects of Calcium in Conjunction With Multi-mineral Supplementation), which is not on this map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Calcium in Conjunction With Multi-mineral Supplementation (Aquamin) on Gut Microbes and Microbially-derived Metabolites in Subjects at Risk for Colon Cancer in a Randomized Controlled Trial
Who cites it
26 citing papers in PubMed, 82 citations in OpenAlex.
- Trial
- A Multi-Mineral Intervention to Modulate Colonic Mucosal Protein Profile: Results from a 90-Day Trial in Human Subjects.Nutrients · 2021Trial
- The Beneficial Effects of Marine Plant-Derived Compounds on the Musculoskeletal System.International journal of molecular sciences · 2026Review
- Exacerbating effects of Western dietary habits on experimentally induced periodontitis in rats.Odontology · 2025Article
- Red Algae Alters Expression of Inflammatory Pathways in an OsteoarthritisPharmaceuticals (Basel, Switzerland) · 2025Article
- Evaluation of dietary supplementation ofFrontiers in veterinary science · 2024Article
- Chemical-functional characterization ofFrontiers in veterinary science · 2024Article
- Bioactivity ofPharmaceuticals (Basel, Switzerland) · 2023Article
- Red Marine AlgaeMarine drugs · 2023Article
- Preparation of Seaweed Nanopowder Particles Using Planetary Ball Milling and Their Effects on Some Secondary Metabolites in Date Palm (Life (Basel, Switzerland) · 2022Article
- Disease-Modifying Adjunctive Therapy (DMAT) in Osteoarthritis-The Biological Effects of a Multi-Mineral Complex, LithoLexalClinics and practice · 2021Review
- Germination Improves the Polyphenolic Profile and Functional Value of Mung Bean (Antioxidants (Basel, Switzerland) · 2020Article
- Evaluation of acute and sub-chronic toxicity ofToxicology reports · 2020Article
- Article
- Hexane Fraction ofFrontiers in endocrinology · 2019Article
- Bioactive Compounds from Marine Organisms: Potential for Bone Growth and Healing.Marine drugs · 2018Review
- Calcium-Induced Differentiation of Human Colon Adenomas in Colonoid Culture: Calcium Alone versus Calcium with Additional Trace Elements.Cancer prevention research (Philadelphia, Pa.) · 2018Article
- Feasibility single-arm study of a medical device containingCancer management and research · 2018Article
- Iodine concentration of milk-alternative drinks available in the UK in comparison with cows' milk.The British journal of nutrition · 2017Article
- Bone structure and function in male C57BL/6 mice: Effects of a high-fat Western-style diet with or without trace minerals.Bone reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The purpose of this study was to determine whether a mineral-rich extract derived from the red marine algae Lithothamnion calcareum could be used as a dietary supplement for prevention of bone mineral loss. Sixty C57BL/6 mice were divided into three groups based on diet: the first group received a high-fat Western-style diet (HFWD), the second group was fed the same HFWD along with the mineral-rich extract included as a dietary supplement, and the third group was used as a control and was fed a low-fat rodent chow diet (AIN76A). Mice were maintained on the respective diets for 15 months. Then, long bones (femora and tibiae) from both males and females were analyzed by three-dimensional micro-computed tomography (micro-CT) and (bones from female mice) concomitantly assessed in bone strength studies. Tartrate-resistant acid phosphatase (TRAP), osteocalcin, and N-terminal peptide of type I procollagen (PINP) were assessed in plasma samples obtained from female mice at the time of sacrifice. To summarize, female mice on the HFWD had reduced bone mineralization and reduced bone strength relative to female mice on the low-fat chow diet. The bone defects in female mice on the HFWD were overcome in the presence of the mineral-rich supplement. In fact, female mice receiving the mineral-rich supplement in the HFWD had better bone structure/function than did female mice on the low-fat chow diet. Female mice on the mineral-supplemented HFWD had higher plasma levels of TRAP than mice of the other groups. There were no differences in the other two markers. Male mice showed little diet-specific differences by micro-CT.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.