ArticleAnnals of surgical oncology2010
Extended esophagectomy in elderly patients with esophageal cancer: minor effect of age alone in determining the postoperative course and survival.
Article in Annals of surgical oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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41 citing papers in PubMed, 1 synthesis or guideline pooled it, 104 citations in OpenAlex.
- Prehabilitation Reduces Occurrence of Anastomotic Leaks After Esophagectomy-A Retrospective Cohort Analysis and Meta-analysis.Journal of gastrointestinal cancer · 2025Pooled it
- Clinical outcome of elderly patients (≥ 70 years) with esophageal cancer undergoing definitive or neoadjuvant radio(chemo)therapy: a retrospective single center analysis.Radiation oncology (London, England) · 2018Trial
- MFI-11 in Chinese elderly esophageal cancer patients with postoperative adverse outcomes.BMC geriatrics · 2024Article
- Two distinct age-prognosis patterns in patients with esophageal cancer undergoing surgical and radiotherapy treatments: a combined analysis of 3JECROG and SEER databases.Therapeutic advances in medical oncology · 2024Article
- Impact of Age on the Treatment and Survival in Esophagogastric Cancer.Annals of surgical oncology · 2023Article
- Real-world management and outcomes of older patients with locally advanced esophageal squamous cell carcinoma: a multicenter retrospective study.BMC cancer · 2023Article
- Outcomes of elderly patients following thoracoscopic esophagectomy for esophageal cancer.Langenbeck's archives of surgery · 2023Article
- Risk stratification of postoperative cardiopulmonary toxicity after trimodality therapy for esophageal cancer.Frontiers in oncology · 2023Article
- Esophageal cancer: Outcome and potential benefit of esophagectomy in elderly patients.Thoracic cancer · 2022Article
- Esophageal Cancer in Elderly Patients, Current Treatment Options and Outcomes; A Systematic Review and Pooled Analysis.Cancers · 2021Review
- Perioperative mortality of head and neck cancers.BMC cancer · 2021Article
- Impact of Age on Surgical Outcomes for Locally Advanced Esophageal Cancer.The Annals of thoracic surgery · 2021Article
- Outcomes of curative esophageal cancer surgery in elderly: A meta-analysis.World journal of gastrointestinal oncology · 2021Article
- Patient Age and Survival After Surgery for Esophageal Cancer.Annals of surgical oncology · 2021Article
- Feasibility of subtotal esophagectomy with systematic lymphadenectomy in selected elderly patients with esophageal cancer; a propensity score matching analysis.BMC surgery · 2019Article
- Changes in the nutritional status of elderly patients after esophagectomy.Esophagus : official journal of the Japan Esophageal Society · 2019Article
- Impact of Age and Comorbidity on Choice and Outcome of Two Different Treatment Options for Patients with Potentially Curable Esophageal Cancer.Annals of surgical oncology · 2019Article
- Treatment and clinical outcome of clinical T4 esophageal cancer: A systematic review.Annals of gastroenterological surgery · 2019Review
- Influence of Patients' Age in the Utilization of Esophagectomy for Esophageal Adenocarcinoma.Journal of laparoendoscopic & advanced surgical techniques. Part A · 2019Article
- Management of Locally Advanced and Metastatic Esophageal Cancer in the Older Population.Current oncology reports · 2018Review
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7 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundElderly patients who undergo esophagectomy for cancer often have a high prevalence of coexisting diseases, which may adversely affect their postoperative course. We determined the relationship of advanced age (i.e., > or =70 years) with outcome and evaluated age as a selection criterion for surgery.
methodsBetween January 1991 and January 2007, we performed a curative-intent extended transthoracic esophagectomy in 234 patients with cancer of the esophagus. Patients were divided into two age groups: <70 years (group I; 170 patients) and > or =70 years (group II; 64 patients).
resultsBoth groups were comparable regarding comorbidity (American Society of Anesthesiologists classification), and tumor and surgical characteristics. The overall in-hospital mortality rate was 6.2% (group I, 5%, vs. group II, 11%, P = 0.09). Advanced age was not a prognostic factor for developing postoperative complications (odds ratio, 1.578; 95% confidence interval, 0.857-2.904; P = 0.143). The overall number of complications was equal with 58% in group I vs. 69% in group II (P = 0.142). Moreover, the occurrence of complications in elderly patients did not influence survival (P = 0.174). Recurrences developed more in patients <70 years (58% vs. 42%, P = 0.028). The overall 5-year survival was 35%, and, when included, postoperative mortality was 33% in both groups (P = 0.676).The presence of comorbidity was an independent prognostic factor for survival (P = 0.002).
conclusionsAdvanced age (> or =70 years) has minor influence on postoperative course, recurrent disease, and survival in patients who underwent an extended esophagectomy. Age alone is not a prognostic indicator for survival. We propose that a radical resection should not be withheld in elderly patients with limited frailty and comorbidity.
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