ReviewCurrent genetics2010
Is the mitochondrial cloud the selection machinery for preferentially transmitting wild-type mtDNA between generations? Rewinding Müller's ratchet efficiently.
Review in Current genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Analysis of Bush Cricket Oogenesis Provides an Insight into the Function and Anagenesis of an Enigmatic Organelle Assemblage: The Balbiani Body.Results and problems in cell differentiation · 2026Article
- Aging through the lens of mitochondrial DNA mutations and inheritance paradoxes.Biogerontology · 2024Review
- Characterization and trans-generation dynamics of mitogene pool in the silver carp (Hypophthalmichthys molitrix).G3 (Bethesda, Md.) · 2024Article
- Balbiani body of basal insects is potentially involved in multiplication and selective elimination of mitochondria.Scientific reports · 2024Article
- Effects of adverse fertility-related factors on mitochondrial DNA in the oocyte: a comprehensive review.Reproductive biology and endocrinology : RB&E · 2023Review
- Bioenergetic consequences of sex-specific mitochondrial DNA evolution.Proceedings. Biological sciences · 2021Article
- The need for high-quality oocyte mitochondria at extreme ploidy dictates mammalian germline development.eLife · 2021Article
- Mitonuclear Coevolution, but not Nuclear Compensation, Drives Evolution of OXPHOS Complexes in Bivalves.Molecular biology and evolution · 2021Article
- Mitochondrial DNA segregation and replication restrict the transmission of detrimental mutation.The Journal of cell biology · 2020Article
- Review
- A battle for transmission: the cooperative and selfish animal mitochondrial genomes.Open biology · 2019Review
- Mutation-specific effects in germline transmission of pathogenic mtDNA variants.Human reproduction (Oxford, England) · 2018Article
- Selection of mitochondria in female germline cells: is Balbiani body implicated in this process?Journal of assisted reproduction and genetics · 2017Review
- Intra-individual purifying selection on mitochondrial DNA variants during human oogenesis.Human reproduction (Oxford, England) · 2017Article
- Mitochondrial membrane potential: a trait involved in organelle inheritance?Biology letters · 2015Article
- Mitochondrial activity in gametes and transmission of viable mtDNA.Biology direct · 2015Article
- Selective propagation of functional mitochondrial DNA during oogenesis restricts the transmission of a deleterious mitochondrial variant.Nature genetics · 2014Article
- Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors.Human molecular genetics · 2013Article
- Mitochondrial DNA genetics and the heteroplasmy conundrum in evolution and disease.Cold Spring Harbor perspectives in biology · 2013Review
- Purification of mitochondrial proteins HSP60 and ATP synthase from ascidian eggs: implications for antibody specificity.PloS one · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In animal mitochondrial DNA inheritance, it remains largely unclear where the mitochondrial genetic bottleneck localizes and how it works in rewinding Müller's ratchet. In a variety of different animals germ plasm mRNAs typically aggregate along with numerous mitochondria to form the mitochondrial cloud (MC) during oogenesis. The MC has been found to serve as messenger transport organizer for germ plasm mRNAs. Germ plasm RNAs in MC will specifically distribute to the primordial germ cells of the future embryo. It has been proposed that the MC might be the site where selected mitochondria accumulate for specific transmission to grandchildren but this idea received relatively little attention and the criterion by which mitochondria are selected remains unknown. Our recent results in zebrafish provided further evidence for selective mitochondria accumulation in the MC by showing that mitochondria with high-inner membrane potential tend to be recruited preferentially into the MC, and these mitochondria are transported along with germ plasm to the cortex of the vegetal pole. By analyzing the composition, behavior and functions of the MC, and in reviewing related literature, we found strong support for the proposition that the MC corresponds to the position and function of the mitochondrial genetic bottleneck.
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