ArticleEuropean journal of human genetics : EJHG2010
Polymorphisms in the IL2, IL2RA and IL2RB genes in multiple sclerosis risk.
Article in European journal of human genetics : EJHG, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Meta-analysis of the Selected Genetic Variants in Immune-Related Genes and Multiple Sclerosis Risk.Molecular neurobiology · 2024Pooled it
- Pooled it
- Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function.Journal of immunology (Baltimore, Md. : 1950) · 2012Trial
- Primary Progressive Multiple Sclerosis: New Therapeutic Approaches.Neuropsychopharmacology reports · 2025Review
- Integrative Analysis of Plasma Proteome and Genome Reveals Novel Drug Targets for Chronic Rhinosinusitis and Nasal Polyps.World journal of otorhinolaryngology - head and neck surgery · 2025Article
- Uncovering genomic diversity and signatures of selection in red Angus × Chinese red steppe crossbred cattle population.Scientific reports · 2025Article
- Circular RNAs in Immune-Related Diseases.Advances in experimental medicine and biology · 2025Review
- Establishment of a diagnostic model based on immune-related genes in children with asthma.Heliyon · 2024Article
- Unraveling the genetic basis of the causal association between inflammatory cytokines and osteonecrosis.Frontiers in endocrinology · 2024Article
- Article
- IL2RB Is a Prognostic Biomarker Associated with Immune Infiltrates in Pan-Cancer.Journal of oncology · 2022Article
- A Two-Gene-Based Diagnostic Signature for Ruptured Intracranial Aneurysms.Frontiers in cardiovascular medicine · 2021Article
- Association ofReports of biochemistry & molecular biology · 2020Article
- Analysis of Single Nucleotide Polymorphisms inReports of biochemistry & molecular biology · 2020Article
- Environmental Influencers, MicroRNA, and Multiple Sclerosis.Journal of central nervous system disease · 2020Review
- Article
- Genetic analysis of the relation between IL2RA/IL2RB and rheumatoid arthritis risk.Molecular genetics & genomic medicine · 2019Article
- Dynamic demethylation of the IL2RA promoter during in vitro CD4+ T cell activation in association with IL2RA expression.Epigenetics · 2018Article
- Therapeutic efficacy of monthly subcutaneous injection of daclizumab in relapsing multiple sclerosis.Biologics : targets & therapy · 2016Review
- Regulatory T cell proliferative potential is impaired in human autoimmune disease.Nature medicine · 2014Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin (IL)-2/IL-2R signalling promotes proliferation and survival of activated T cells and has an essential non-redundant role in the production of regulatory T cells. Associations with different autoimmune diseases of polymorphisms in a linkage disequilibrium block in which the IL2/IL21 genes map (4q27), and also in genes encoding the IL2RA and IL2RB subunits (located in 10p15 and 22q13, respectively), were identified through genome-wide studies. Polymorphisms in these three genes were studied in 430 multiple sclerosis (MS) patients and in 550 ethnically matched controls from Madrid (Spain). Replication and meta-analysis with results from an independent cohort of 771 MS patients and 759 controls from Andalucía (Spain) confirmed the association of polymorphisms in the IL2RA gene (P(Mantel-Haenszel,) odds ratio (OR)(M-H) (95% confidence interval, CI) for rs2104286: 0.0001, 0.75 (0.65-0.87); for rs11594656/rs35285258: 0.004, 1.19 (1.06-1.34); for rs41295061: 0.03, 0.77 (0.60-0.98)); showed a trend for association of the IL2/IL21 rs6822844 (P(M-H)=0.07, OR(M-H) (95% CI)=0.86 (0.73-1.01)), but did not corroborate the association for IL2RB. Regression analyses of the combined Spanish cohort revealed the independence of two IL2RA association signals: rs2104286 and rs11594656/rs35285258. The relevant role of the IL2RA gene on MS susceptibility adds support to its common effect on autoimmune risk and the suggestive association of IL2/IL21 warrants further investigation.
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