ArticleAnesthesiology2010
Mild endotoxemia during mechanical ventilation produces spatially heterogeneous pulmonary neutrophilic inflammation in sheep.
Article in Anesthesiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 65 citations in OpenAlex.
- Positron Emission Tomography With 18F-Fluorodeoxyglucose in Patients With Sickle Cell Acute Chest Syndrome.Medicine · 2015Trial
- Modeling Ventilator-Induced Lung Injury and Neutrophil Infiltration to Infer Injury Interdependence.Annals of biomedical engineering · 2023Article
- Development of lung cancer risk prediction models based on F-18 FDG PET images.Annals of nuclear medicine · 2023Article
- Worsening of lung perfusion to tissue density distributions during early acute lung injury.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Molecular imaging of inflammation with PET in acute and ventilator-induced lung injury.Frontiers in physiology · 2023Review
- Intraoperative Protective Mechanical Ventilation: Fact or Fiction?Anesthesiology · 2022Article
- Spatiotemporal distribution of cellular injury and leukocytes during the progression of ventilator-induced lung injury.American journal of physiology. Lung cellular and molecular physiology · 2022Article
- Perioperative Pulmonary Atelectasis: Part II. Clinical Implications.Anesthesiology · 2022Review
- Distribution and Magnitude of Regional Volumetric Lung Strain and Its Modification by PEEP in Healthy Anesthetized and Mechanically Ventilated Dogs.Frontiers in veterinary science · 2022Article
- Protective ventilation during surgery: Do lower tidal volumes really matter?Anaesthesia, critical care & pain medicine · 2021Article
- New Frontiers in Functional and Molecular Imaging of the Acutely Injured Lung: Pathophysiological Insights and Research Applications.Frontiers in physiology · 2021Review
- Mechanical Power Correlates With Lung Inflammation Assessed by Positron-Emission Tomography in Experimental Acute Lung Injury in Pigs.Frontiers in physiology · 2021Article
- Lung Atelectasis Promotes Immune and Barrier Dysfunction as Revealed by Transcriptome Sequencing in Female Sheep.Anesthesiology · 2020Article
- Lung protection in acute respiratory distress syndrome: what should we target?Current opinion in critical care · 2020Article
- Driving Pressure and Transpulmonary Pressure: How Do We Guide Safe Mechanical Ventilation?Anesthesiology · 2019Review
- Effects of Positive End-Expiratory Pressure and Spontaneous Breathing Activity on Regional Lung Inflammation in Experimental Acute Respiratory Distress Syndrome.Critical care medicine · 2019Article
- A Window on the Lung: Molecular Imaging as a Tool to Dissect Pathophysiologic Mechanisms of Acute Lung Disease.Contrast media & molecular imaging · 2019Review
- Deterioration of Regional Lung Strain and Inflammation during Early Lung Injury.American journal of respiratory and critical care medicine · 2018Article
- Follow the Voxel-A New Method for the Analysis of Regional Strain in Lung Injury.Critical care medicine · 2018Article
- Quantification of Lung PET Images: Challenges and Opportunities.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2017Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThere is limited information on the regional inflammatory effects of mechanical ventilation and endotoxemia on the production of acute lung injury. Measurement of F-fluorodeoxyglucose (F-FDG) uptake with positron emission tomography allows for the regional, in vivo and noninvasive, assessment of neutrophilic inflammation. The authors tested whether mild endotoxemia combined with large tidal volume mechanical ventilation bounded by pressures within clinically acceptable limits could yield measurable and anatomically localized neutrophilic inflammation.
methodsSheep were mechanically ventilated with plateau pressures = 30-32 cm H2O and positive end-expiratory pressure = 0 for 2 h. Six sheep received intravenous endotoxin (10 ng x kg x min), whereas six did not (controls), in sequentially performed studies. The authors imaged with positron emission tomography the intrapulmonary kinetics of infused N-nitrogen and F-FDG to compute regional perfusion and F-FDG uptake. Transmission scans were used to assess aeration.
resultsMean gas fraction and perfusion distribution were similar between groups. In contrast, a significant increase in F-FDG uptake was observed in all lung regions of the endotoxin group. In this group, F-FDG uptake in the middle and dorsal regions was significantly larger than that in the ventral regions. Multivariate analysis showed that the F-FDG uptake was associated with regional aeration (P < 0.01) and perfusion (P < 0.01).
conclusionsMild short-term endotoxemia in the presence of heterogeneous lung aeration and mechanical ventilation with pressures within clinically acceptable limits produces marked spatially heterogeneous increases in pulmonary neutrophilic inflammation. The dependence of inflammation on aeration and perfusion suggests a multifactorial basis for that finding. F-FDG uptake may be a sensitive marker of pulmonary neutrophilic inflammation in the studied conditions.
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