ArticleActa crystallographica. Section D, Biological crystallography2010
Structure of the unbound form of HIV-1 subtype A protease: comparison with unbound forms of proteases from other HIV subtypes.
Article in Acta crystallographica. Section D, Biological crystallography, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Structural Catalytic Core of the Members of the Superfamily of Acid Proteases.Molecules (Basel, Switzerland) · 2024Review
- Article
- The evolution of the HIV-1 protease folding stability.Virus evolution · 2022Article
- Optimizing the refinement of merohedrally twinned P6Acta crystallographica. Section D, Structural biology · 2020Article
- An insight to the molecular interactions of the FDA approved HIV PR drugs against L38L↑N↑L PR mutant.Journal of computer-aided molecular design · 2018Article
- Effects of Hinge-region Natural Polymorphisms on Human Immunodeficiency Virus-Type 1 Protease Structure, Dynamics, and Drug Pressure Evolution.The Journal of biological chemistry · 2016Article
- Pulsed EPR characterization of HIV-1 protease conformational sampling and inhibitor-induced population shifts.Physical chemistry chemical physics : PCCP · 2016Article
- Conformational variation of an extreme drug resistant mutant of HIV protease.Journal of molecular graphics & modelling · 2015Article
- Conformation of inhibitor-free HIV-1 protease derived from NMR spectroscopy in a weakly oriented solution.Chembiochem : a European journal of chemical biology · 2015Article
- Spin labeling and Double Electron-Electron Resonance (DEER) to Deconstruct Conformational Ensembles of HIV Protease.Methods in enzymology · 2015Article
- HIV control is mediated in part by CD8+ T-cell targeting of specific epitopes.Journal of virology · 2014Article
- HIV transmission. Selection bias at the heterosexual HIV-1 transmission bottleneck.Science (New York, N.Y.) · 2014Article
- Evaluation of novel Saquinavir analogs for resistance mutation compatibility and potential as an HIV-Protease inhibitor drug.Bioinformation · 2014Article
- The HIVToolbox 2 web system integrates sequence, structure, function and mutation analysis.PloS one · 2014Article
- Elucidating the energetics of entropically driven protein-ligand association: calculations of absolute binding free energy and entropy.The journal of physical chemistry. B · 2011Article
- Insights into the dynamics of HIV-1 protease: a kinetic network model constructed from atomistic simulations.Journal of the American Chemical Society · 2011Article
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10 authors.
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Abstract
The crystal structure of the unbound form of HIV-1 subtype A protease (PR) has been determined to 1.7 A resolution and refined as a homodimer in the hexagonal space group P6(1) to an R(cryst) of 20.5%. The structure is similar in overall shape and fold to the previously determined subtype B, C and F PRs. The major differences lie in the conformation of the flap region. The flaps in the crystal structures of the unbound subtype B and C PRs, which were crystallized in tetragonal space groups, are either semi-open or wide open. In the present structure of subtype A PR the flaps are found in the closed position, a conformation that would be more anticipated in the structure of HIV protease complexed with an inhibitor. The amino-acid differences between the subtypes and their respective crystal space groups are discussed in terms of the differences in the flap conformations.
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