ArticleExperimental gerontology2010
Gene regulatory changes in yeast during life extension by nutrient limitation.
Article in Experimental gerontology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Design principles of gene circuits for longevity.Trends in cell biology · 2025Review
- The Role of Metabolic Engineering Technologies for the Production of Fatty Acids in Yeast.Biology · 2021Review
- Plasma methionine metabolic profile is associated with longevity in mammals.Communications biology · 2021Article
- Insights into the Conserved Regulatory Mechanisms of Human and Yeast Aging.Biomolecules · 2020Review
- Heat-induced longevity in budding yeast requires respiratory metabolism and glutathione recycling.Aging · 2018Article
- Adaptation to metabolic dysfunction during aging: Making the best of a bad situation.Experimental gerontology · 2018Review
- Some Metabolites Act as Second Messengers in Yeast Chronological Aging.International journal of molecular sciences · 2018Review
- Dietary restriction and lifespan: Lessons from invertebrate models.Ageing research reviews · 2017Review
- Loss of Nat4 and its associated histone H4 N-terminal acetylation mediates calorie restriction-induced longevity.EMBO reports · 2016Article
- Volvox: A simple algal model for embryogenesis, morphogenesis and cellular differentiation.Developmental biology · 2016Review
- Identification of the Target of the Retrograde Response that Mediates Replicative Lifespan Extension in Saccharomyces cerevisiae.Genetics · 2016Article
- Less is more: Nutrient limitation induces cross-talk of nutrient sensing pathways with NADFrontiers in biology · 2015Article
- Distinct metabolomic signatures are associated with longevity in humans.Nature communications · 2015Article
- Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response.Cell metabolism · 2014Article
- The Aspergillus nidulans ATM kinase regulates mitochondrial function, glucose uptake and the carbon starvation response.G3 (Bethesda, Md.) · 2014Article
- Mitochondrial stress signaling in longevity: a new role for mitochondrial function in aging.Redox biology · 2014Review
- The retrograde response: when mitochondrial quality control is not enough.Biochimica et biophysica acta · 2013Review
- Article
- Down-regulating sphingolipid synthesis increases yeast lifespan.PLoS genetics · 2012Article
- Caloric restriction extends yeast chronological lifespan by altering a pattern of age-related changes in trehalose concentration.Frontiers in physiology · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Genetic analyses aimed at identification of the pathways and downstream effectors of calorie restriction (CR) in the yeast Saccharomyces cerevisiae suggest the importance of central metabolism for the extension of replicative life span by CR. However, the limited gene expression studies to date are not informative, because they have been conducted using cells grown in batch culture which markedly departs from the conditions under which yeasts are grown during life span determinations. In this study, we have examined the gene expression changes that occur during either glucose limitation or elimination of nonessential-amino acids, both of which enhance yeast longevity, culturing cells in a chemostat at equilibrium, which closely mimics conditions they encounter during life span determinations. Expression of 59 genes was examined quantitatively by real-time, reverse transcriptase polymerase chain reaction (qRT-PCR), and the physiological state of the cultures was monitored. Extensive gene expression changes were detected, some of which were common to both CR regimes. The most striking of these was the induction of tricarboxylic acid (TCA) cycle and retrograde response target genes, which appears to be at least partially due to the up-regulation of the HAP4 gene. These gene regulatory events portend an increase in the generation of biosynthetic intermediates necessary for the production of daughter cells, which is the measure of yeast replicative life span.
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