ReviewFEBS letters2010
Mitochondrial ion channels as therapeutic targets.
Review in FEBS letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Review of electrophysiological models to study membrane potential changes in breast cancer cell transformation and tumor progression.Frontiers in physiology · 2025Review
- Routes for Potassium Ions across Mitochondrial Membranes: A Biophysical Point of View with Special Focus on the ATP-Sensitive KBiomolecules · 2021Review
- Mitochondria-Targeted Nanocarriers Promote Highly Efficient Cancer Therapy: A Review.Frontiers in bioengineering and biotechnology · 2021Review
- Natural Products Targeting the Mitochondria in Cancers.Molecules (Basel, Switzerland) · 2020Review
- The protective role of DMBT1 in cervical squamous cell carcinoma.The Kaohsiung journal of medical sciences · 2019Article
- Protective effect of propofol on hydrogen peroxide-induced human esophageal carcinoma via blocking the Wnt/β-catenin signaling pathway.Iranian journal of basic medical sciences · 2018Article
- Identification of new channels by systematic analysis of the mitochondrial outer membrane.The Journal of cell biology · 2017Article
- Divalent cation chelators citrate and EDTA unmask an intrinsic uncoupling pathway in isolated mitochondria.Journal of bioenergetics and biomembranes · 2017Article
- Murine Electrophysiological Models of Cardiac Arrhythmogenesis.Physiological reviews · 2017Review
- Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases.Oxidative medicine and cellular longevity · 2016Review
- Mitochondrial Dynamics and Heart Failure.Comprehensive Physiology · 2015Review
- Mitochondrial Ion Channels in Cancer Transformation.Frontiers in oncology · 2015Review
- Mitochondrial ion channels/transporters as sensors and regulators of cellular redox signaling.Antioxidants & redox signaling · 2014Review
- Endoplasmic reticulum membrane potassium channel dysfunction in high fat diet induced stress in rat hepatocytes.EXCLI journal · 2014Article
- Intracellular ASIC1a regulates mitochondrial permeability transition-dependent neuronal death.Cell death and differentiation · 2013Article
- Mitochondrial targets for arrhythmia suppression: is there a role for pharmacological intervention?Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2013Review
- Mitochondrial small conductance SK2 channels prevent glutamate-induced oxytosis and mitochondrial dysfunction.The Journal of biological chemistry · 2013Article
- The therapeutic potential of mitochondrial channels in cancer, ischemia-reperfusion injury, and neurodegeneration.Mitochondrion · 2012Review
- Mitochondria are sources of metabolic sink and arrhythmias.Pharmacology & therapeutics · 2011Review
- Is mPTP the gatekeeper for necrosis, apoptosis, or both?Biochimica et biophysica acta · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The study of mitochondrial ion channels changed our perception of these double-wrapped organelles from being just the power house of a cell to the guardian of a cell's fate. Mitochondria communicate with the cell through these special channels. Most of the time, the message is encoded by ion flow across the mitochondrial outer and inner membranes. Potassium, sodium, calcium, protons, nucleotides, and proteins traverse the mitochondrial membranes in an exquisitely regulated manner to control a myriad of processes, from respiration and mitochondrial morphology to cell proliferation and cell death. This review is an update on both well established and putative mitochondrial channels regarding their composition, function, regulation, and therapeutic potential.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.