ArticleVirus genes1991
A novel point mutation at codon 146 of the K-ras gene in a human colorectal cancer identified by the polymerase chain reaction.
Article in Virus genes, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.Science signaling · 2011Article
- Activating K-Ras mutations outwith 'hotspot' codons in sporadic colorectal tumours - implications for personalised cancer medicine.British journal of cancer · 2010Article
- Fast simultaneous detection of K-RAS mutations in colorectal cancer.BMC cancer · 2009Article
- High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients.Blood · 2009Article
- Recurrent KRAS codon 146 mutations in human colorectal cancer.Cancer biology & therapy · 2006Article
- p21X mRNA is expressed as a singly spliced pX transcript from defective provirus genomes having a partial deletion of the pol-env region in human T-cell leukemia virus type 1-infected cells.Nucleic acids research · 1993Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
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Abstract
In this report, point mutations of the K-ras gene at codon 146 were analyzed in 25 cases of colon cancer, 4 cases of lung cancer, and 41 cases of lymphoid malignancy. A codon 146 mutation substituting threonine (ACA) for alanine (GCA) was detected in the tumor tissue of a patient with colon cancer and was not detected in the normal tissue of the same patient. Any additional mutations of the ras gene family were not detected in this patient. These results suggest that the codon 146 mutation of the K-ras gene could be involved in the development of naturally occurring human malignancies.
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