ArticleClinical and molecular allergy : CMA2010
Regulation and dysregulation of immunoglobulin E: a molecular and clinical perspective.
Article in Clinical and molecular allergy : CMA, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 83 citations in OpenAlex.
- Development and validation of a clinically applicable biomarker panel for identifying autoimmune type IIb chronic spontaneous urticaria.The World Allergy Organization journal · 2026Article
- Article
- The roles of serum Th1, Th2, and Th17 cytokines in patients with chronic urticaria: a systematic review and meta-analysis.Frontiers in allergy · 2025Review
- Elevated IgE Levels-An Allergy or an Underlying Inborn Error of Immunity in Children with Recurrent Infections?Antibodies (Basel, Switzerland) · 2023Article
- Gene Therapy for Immunoglobulin E, Complement-Mediated, and Eosinophilic Disorders.Human gene therapy · 2023Review
- Increased Serum Levels of Tumor Necrosis Factor-like Ligand 1A in Atopic Dermatitis.International journal of molecular sciences · 2023Article
- Dupilumab-induced ocular surface disease: a primer.BMJ case reports · 2022Article
- Article
- STAT3 gain-of-function is not responsible for low total IgE levels in patients with autoimmune chronic spontaneous urticaria.Frontiers in immunology · 2022Article
- Optimized Extraction of cAMP From Jujube by Ultra-High Pressure Technology and the Anti-allergic Effect for Peanut Allergy Mouse.Frontiers in nutrition · 2022Article
- Is There a Clinical Significance of Very Low Serum Immunoglobulin E Level?Journal of clinical immunology · 2021Article
- Immune Dysregulation in Patients With Chromosome 18q Deletions-Searching for Putative Loci for Autoimmunity and Immunodeficiency.Frontiers in immunology · 2021Article
- Total Serum Immunoglobulin E Levels in Patients with Psoriasis.Materia socio-medica · 2020Article
- Human toxocariasis and atopy.Parasite (Paris, France) · 2020Article
- Risk of Cardiovascular Mortality in Relation to Increased Total Serum IgE Levels in Older Adults: A Population-Based Cohort Study.International journal of environmental research and public health · 2019Article
- THE JEREMIAH METZGER LECTURE NOVEL THERAPEUTIC STRATEGIES OF ALLERGIC AND IMMUNOLOGIC DISORDERS.Transactions of the American Clinical and Climatological Association · 2018Review
- Immunoglobulin E-Mediated Autoimmunity.Frontiers in immunology · 2018Review
- The Relationship of Serum Antigen-Specific and Total Immunoglobulin E with Adult Cardiovascular Diseases.International journal of medical sciences · 2018Article
- Low immunoglobulin E flags two distinct types of immune dysregulation.Clinical and experimental immunology · 2017Article
- Elevated serum immunoglobulin E level as a marker for progression of immunoglobulin A nephropathy.Kidney research and clinical practice · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAltered levels of Immunoglobulin E (IgE) represent a dysregulation of IgE synthesis and may be seen in a variety of immunological disorders. The object of this review is to summarize the historical and molecular aspects of IgE synthesis and the disorders associated with dysregulation of IgE production.
methodsArticles published in Medline/PubMed were searched with the keyword Immunoglobulin E and specific terms such as class switch recombination, deficiency and/or specific disease conditions (atopy, neoplasia, renal disease, myeloma, etc.). The selected papers included reviews, case reports, retrospective reviews and molecular mechanisms. Studies involving both sexes and all ages were included in the analysis.
resultsBoth very low and elevated levels of IgE may be seen in clinical practice. Major advancements have been made in our understanding of the molecular basis of IgE class switching including roles for T cells, cytokines and T regulatory (or Treg) cells in this process. Dysregulation of this process may result in either elevated IgE levels or IgE deficiency.
conclusionEvaluation of a patient with elevated IgE must involve a detailed differential diagnosis and consideration of various immunological and non-immunological disorders. The use of appropriate tests will allow the correct diagnosis to be made. This can often assist in the development of tailored treatments.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.