ArticleBMC infectious diseases2010
Evidence for waning of latency in a cohort study of tuberculosis.
Article in BMC infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 57 citations in OpenAlex.
- Transcriptomic Signatures of Progression to Tuberculosis Disease Among Close Contacts in Brazil.The Journal of infectious diseases · 2024Article
- Overlooked, dismissed, and downplayed: reversion ofEuropean respiratory review : an official journal of the European Respiratory Society · 2024Review
- Evaluation of cytokine profiles related toFrontiers in immunology · 2024Article
- A half-century of research on tuberculosis: Successes and challenges.The Journal of experimental medicine · 2023Article
- The Problem of Host and Pathogen Genetic Variability for Developing Strategies of Universally Efficacious Vaccination against and Personalised Immunotherapy of Tuberculosis: Potential Solutions?International journal of molecular sciences · 2023Article
- Tuberculosis: insights into latency, treatment strategies, and the potential roles of metronidazole.Frontiers in tuberculosis · 2023Review
- End-point definition and trial design to advance tuberculosis vaccine development.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Antigen-Specific T-Cell Activation Distinguishes between Recent and Remote Tuberculosis Infection.American journal of respiratory and critical care medicine · 2021Observational
- BCG-induced protection against Mycobacterium tuberculosis infection: Evidence, mechanisms, and implications for next-generation vaccines.Immunological reviews · 2021Review
- Immune profiling of Mycobacterium tuberculosis-specific T cells in recent and remote infection.EBioMedicine · 2021Article
- Discrimination of 2D wall textures by passive echolocation for different reflected-to-direct level difference configurations.PloS one · 2021Article
- Blood RNA signatures predict recent tuberculosis exposure in mice, macaques and humans.Scientific reports · 2020Article
- Comparison of IFN-γ Levels in Children with Tuberculosis Disease (TB) and Latent Tuberculosis Infection (LTBI).Open access Macedonian journal of medical sciences · 2018Article
- Altered monocyte phenotypes but not impaired peripheral T cell immunity may explain susceptibility of the elderly to develop tuberculosis.Experimental gerontology · 2018Observational
- Revisiting the timetable of tuberculosis.BMJ (Clinical research ed.) · 2018Article
- The global burden of tuberculosis: results from the Global Burden of Disease Study 2015.The Lancet. Infectious diseases · 2018Article
- Immigrant screening for latent tuberculosis in Norway: a cost-effectiveness analysis.The European journal of health economics : HEPAC : health economics in prevention and care · 2017Article
- Human Immunology of Tuberculosis.Microbiology spectrum · 2017Review
- Tuberculosis in Cape Town: An age-structured transmission model.Epidemics · 2016Article
- Tuberculosis vaccines and prevention of infection.Microbiology and molecular biology reviews : MMBR · 2014Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate how the risk of active tuberculosis disease is influenced by time since original infection and to determine whether the risk of reactivation of tuberculosis increases or decreases with age.
methodsCohort analysis of data for the separate ten year birth cohorts of 1876-1885 to 1959-1968 obtained from Statistics Norway and the National Tuberculosis Registry. These data were used to calculate the rates and the changes in the rates of bacillary (or active) tuberculosis. Data on bacillary tuberculosis for adult (20+) age groups were obtained from the National Tuberculosis Registry and Statistics Norway from 1946 to 1974. Most cases during this period arose due to reactivation of remote infection. Participants in this part of the analysis were all reported active tuberculosis cases in Norway from 1946 to 1974 as recorded in the National Tuberculosis Registry.
resultsTuberculosis decreased at a relatively steady rate when following individual birth cohorts, but with a tendency of slower decline as time passed since infection. A mean estimate of this rate of decline was 57% in a 10 year period.
conclusionsThe risk of reactivation of latent tuberculosis decreases with age. This decline may reflect the rate at which latent tuberculosis is eliminated from a population with minimal transmission of tubercle bacilli. A model for risk of developing active tuberculosis as a function of time since infection shows that the rate at which tuberculosis can be eliminated from a society can be quite substantial if new infections are effectively prevented. The findings clearly indicate that preventative measures against transmission of tuberculosis will be the most effective. These results also suggest that the total population harbouring live tubercle bacilli and consequently the future projection for increased incidence of tuberculosis in the world is probably overestimated.
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Registered trials
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