ArticleBMC developmental biology2010
Spatial discontinuity of optomotor-blind expression in the Drosophila wing imaginal disc disrupts epithelial architecture and promotes cell sorting.
Article in BMC developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Toll receptors mediate tissue intrinsic surveillance against aberrant cells by detecting cell fate aberrations.Development (Cambridge, England) · 2026Article
- Elimination of aberrantly specified cell clones is independent of interfacial Myosin II accumulation.Journal of cell science · 2023Article
- Bilateral JNK activation is a hallmark of interface surveillance and promotes elimination of aberrant cells.eLife · 2023Article
- ChIP-seq profiling of H3K4me3 and H3K27me3 in an invasive insect,Frontiers in genetics · 2023Article
- Transcriptome profiling for developmental stages Protaetia brevitarsis seulensis with focus on wing development and metamorphosis.PloS one · 2023Article
- Functional identity of hypothalamic melanocortin neurons depends on Tbx3.Nature metabolism · 2019Article
- Functional variants in TBX2 are associated with a syndromic cardiovascular and skeletal developmental disorder.Human molecular genetics · 2018Article
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- Fold formation at the compartment boundary of Drosophila wing requires Yki signaling to suppress JNK dependent apoptosis.Scientific reports · 2016Article
- Asymmetric distribution of Spalt in Drosophila wing squamous and columnar epithelia ensures correct cell morphogenesis.Scientific reports · 2016Article
- Interface Contractility between Differently Fated Cells Drives Cell Elimination and Cyst Formation.Current biology : CB · 2016Article
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- Article
- The Spalt Transcription Factors Generate the Transcriptional Landscape of the Drosophila melanogaster Wing Pouch Central Region.PLoS genetics · 2015Article
- Muscle cell fate choice requires the T-box transcription factor midline in Drosophila.Genetics · 2015Article
- Optomotor-blind negatively regulates Drosophila eye development by blocking Jak/STAT signaling.PloS one · 2015Article
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- Article
- Article
- Dpp signaling activity requires Pentagone to scale with tissue size in the growing Drosophila wing imaginal disc.PLoS biology · 2011Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundDecapentaplegic (Dpp) is one of the best characterized morphogens, required for dorso-ventral patterning of the Drosophila embryo and for anterior-posterior (A/P) patterning of the wing imaginal disc. In the larval wing pouch, the Dpp target gene optomotor-blind (omb) is generally assumed to be expressed in a step function above a certain threshold of Dpp signaling activity.
resultsWe show that the transcription factor Omb forms, in fact, a symmetrical gradient on both sides of the A/P compartment boundary. Disruptions of the Omb gradient lead to a re-organization of the epithelial cytoskeleton and to a retraction of cells toward the basal membrane suggesting that the Omb gradient is required for correct epithelial morphology. Moreover, by analysing the shape of omb gain- and loss-of-function clones, we find that Omb promotes cell sorting along the A/P axis in a concentration-dependent manner.
conclusionsOur findings show that Omb distribution in the wing imaginal disc is described by a gradient rather than a step function. Graded Omb expression is necessary for normal cell morphogenesis and cell affinity and sharp spatial discontinuities must be avoided to allow normal wing development.
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