ArticleBMC research notes2010
Emergence of KPC-producing Klebsiella pneumoniae in Italy.
Article in BMC research notes, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 44 citations in OpenAlex.
- Ten Years of KPC-Kp Bloodstream Infections Experience: Impact of Early Appropriate Empirical Therapy on Mortality.Biomedicines · 2022Article
- Emerging carbapenem-resistantMicrobial genomics · 2021Article
- Whole-genome sequencing of Klebsiella pneumoniae MDR strain isolated in a Syrian refugee.Pathogens and global health · 2017Article
- The carbapenem-resistant Enterobacteriaceae threat is growing: NDM-1 epidemic at a training hospital in Turkey.Annals of clinical microbiology and antimicrobials · 2016Article
- Epidemiology of Carbapenem Resistant Klebsiella pneumoniae Infections in Mediterranean Countries.Mediterranean journal of hematology and infectious diseases · 2016Review
- Emerging diseases in Bangladesh: Current microbiological research perspective.Tzu chi medical journal · 2015Review
- Infections by carbapenem-resistant Klebsiella pneumoniae in SCT recipients: a nationwide retrospective survey from Italy.Bone marrow transplantation · 2015Article
- Multiplex real-time PCR probe-based for identification of strains producing: OXA48, VIM, KPC and NDM.World journal of microbiology & biotechnology · 2014Article
- Detection of Carbapenemase Production in Gram-negative Bacteria.Journal of laboratory physicians · 2014Article
- Article
- Genomics of KPC-producing Klebsiella pneumoniae sequence type 512 clone highlights the role of RamR and ribosomal S10 protein mutations in conferring tigecycline resistance.Antimicrobial agents and chemotherapy · 2014Article
- Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases.The Lancet. Infectious diseases · 2013Review
- Containment of an outbreak of KPC-3-producing Klebsiella pneumoniae in Italy.Journal of clinical microbiology · 2011Article
- Multiplex real-time PCR assay for detection and classification of Klebsiella pneumoniae carbapenemase gene (bla KPC) variants.Journal of clinical microbiology · 2011Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe emergence of KPC-producing K. pneumoniae has now become a global concern. KPC beta-lactamases are plasmid-borne and, like extended spectrum beta lactamases (ESBLs), can accumulate and transfer resistance determinants to other classes of antibiotics. Therefore, infection control guidelines on early identification and control of the spread of organisms carrying these resistant determinants are needed.
findingsKlebsiella pneumoniae carbapenemase (KPC) was detected in two isolates of carbapenem-resistant K. pneumoniae obtained from patients at an Italian teaching hospital. The first strain was isolated from a culture drawn from a central venous device (CVC) in a patient with Crohn's disease who was admitted to a gastroenterology ward. The second was isolated from a urine sample collected from an indwelling urinary catheter in an intensive care unit (ICU) patient with a subdural haematoma. The patients had not travelled abroad. Both isolates were resistant to all beta-lactams and were susceptible to imipenem and meropenem but resistant to ertapenem. Isolates also showed resistance to other classes of non-beta-lactam antibiotics, such as quinolones, aminoglycosides (with the exception for amikacin), trimethoprim-sulfamethoxazole (TMP-SMX) and nitrofurantoin. They were determined to contain the plasmid encoding the carbapenemase gene bla-KPC and were also positive in the Hodge test.
conclusionsThis is the second report of KPC-producing isolates in Italy, but the first concerning KPC type 2 gene, and it may have important implications for controlling the transmission of microorganisms resistant to antibiotics.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.