ArticleGenome biology2010
Immunity and other defenses in pea aphids, Acyrthosiphon pisum.
Article in Genome biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 210 papers.
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210 citing papers in PubMed.
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- Insects as a New Source of Biomolecules and their Application in Agroindustry, Cosmetics and Pharmacology.Cell biochemistry and biophysics · 2026Review
- Transcriptomic analysis reveals members and expression characteristics of innate immunity genes in Chinese scorpion Mesobuthus martensii.Scientific reports · 2026Article
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- Absence of conserved immune signalling pathways and increased pathogen susceptibility associated to photosymbiosis in acoels.BMC biology · 2026Article
- New potential antimicrobial peptides with mirror-symmetrical structure in fungi and insects.Frontiers in microbiology · 2026Article
- Aphid-killing bacteria: diversity, origin, mechanisms and biocontrol potential.Frontiers in microbiology · 2026Review
- Traits analysis of an aphid-killingFrontiers in insect science · 2026Article
- Insect immune systems: same same but different but still same.Frontiers in immunology · 2026Review
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- AcMNPV, a viral insecticide of Lepidoptera pests, stimulates the immune response of the natural enemyApplied and environmental microbiology · 2025Article
- Functionality of highly diverged Imd like genes identified in stinkbugs and bedbugs.Scientific reports · 2025Article
- Oxidative, Genotoxic and Epigenotoxic Effects of Pimpla turionellae Venom at Pharmacological Perspective.Neotropical entomology · 2025Article
- Morphotype-Specific Antifungal Defense inInsects · 2025Article
- A dual insect symbiont and plant pathogen improves insect host fitness under arginine limitation.mBio · 2025Article
- Integrated microbiome and metabolomic analysis of Spodoptera litura under Metarhizium flavoviride qc1401 stress.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Immune-Related Genes in the Honey Bee MiteInsects · 2025Article
- Entomopathogenic Bacteria Species and Toxins Targeting Aphids (Hemiptera: Aphididae): A Review.Plants (Basel, Switzerland) · 2025Review
- The Role of AaPGRP-LB in the Immune Response ofInternational journal of molecular sciences · 2025Article
150 more citing papers are in PubMed but not listed here.
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Authors and funding
26 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent genomic analyses of arthropod defense mechanisms suggest conservation of key elements underlying responses to pathogens, parasites and stresses. At the center of pathogen-induced immune responses are signaling pathways triggered by the recognition of fungal, bacterial and viral signatures. These pathways result in the production of response molecules, such as antimicrobial peptides and lysozymes, which degrade or destroy invaders. Using the recently sequenced genome of the pea aphid (Acyrthosiphon pisum), we conducted the first extensive annotation of the immune and stress gene repertoire of a hemipterous insect, which is phylogenetically distantly related to previously characterized insects models.
resultsStrikingly, pea aphids appear to be missing genes present in insect genomes characterized to date and thought critical for recognition, signaling and killing of microbes. In line with results of gene annotation, experimental analyses designed to characterize immune response through the isolation of RNA transcripts and proteins from immune-challenged pea aphids uncovered few immune-related products. Gene expression studies, however, indicated some expression of immune and stress-related genes.
conclusionsThe absence of genes suspected to be essential for the insect immune response suggests that the traditional view of insect immunity may not be as broadly applicable as once thought. The limitations of the aphid immune system may be representative of a broad range of insects, or may be aphid specific. We suggest that several aspects of the aphid life style, such as their association with microbial symbionts, could facilitate survival without strong immune protection.
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