ArticleParasitology research2010
ES proteins analysis of Angiostrongylus cantonensis: products of the potential parasitism genes?
Article in Parasitology research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Proteomic Profiling and In Silico Characterization of the Secretome ofPathogens (Basel, Switzerland) · 2022Article
- 3-Hydroxybenzaldehyde and 4-Hydroxybenzaldehyde enhance survival of mouse astrocytes treated with Angiostrongylus cantonensis young adults excretory/secretory products.Biomedical journal · 2021Article
- Immunomodulatory action of excretory-secretory products of Angiostrongylus cantonensis in a mouse tumour model.Parasitology research · 2020Article
- Excretory/secretory products of Angiostrongylus cantonensis fifth-stage larvae induce endoplasmic reticulum stress via the Sonic hedgehog pathway in mouse astrocytes.Parasites & vectors · 2020Article
- Identification of a phenoloxidase- and melanin-dependent defence mechanism in Achatina fulica infected with Angiostrongylus vasorum.Parasites & vectors · 2018Article
- Cloning and characterization of the first serine carboxypeptidase from a plant parasitic nematode, Radopholus similis.Scientific reports · 2017Article
- Comparative studies on the proteomic expression patterns in the third- and fifth-stage larvae of Angiostrongylus cantonensis.Parasitology research · 2014Article
- Identification and characterisation of microRNAs in young adults of Angiostrongylus cantonensis via a deep-sequencing approach.Memorias do Instituto Oswaldo Cruz · 2013Article
- Transcriptome profiling of the fifth-stage larvae of Angiostrongylus cantonensis by next-generation sequencing.Parasitology research · 2013Article
- The mRNA level of the galectin-10 of Angiostrongylus cantonensis induced by reactive oxygen stress.Parasitology research · 2013Article
- Molecular cloning, expression, and characterization of a putative activation-associated secreted protein from Angiostrongylus cantonensis.Parasitology research · 2013Article
- Molecular cloning and characterization of a matrix metalloproteinase, from Caenorhabditis elegans: employed to identify homologous protein from Angiostrongylus cantonensis.Parasitology research · 2012Article
- Human Angiostrongylus cantonensis: an update.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Review
- Interface Molecules of Angiostrongylus cantonensis: Their Role in Parasite Survival and Modulation of Host Defenses.International journal of inflammation · 2012Article
- Elimination of Angiostrongylus costaricensis larvae in feces from experimentally infected Swiss mice: circadian rhythm and correlation with survival.Parasitology research · 2011Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expressed sequence tags (ESTs) of Angiostrongylus cantonensis were analyzed in an attempt to gain further insight into its genomic expression patterns. A total of 1,277 ESTs of A. cantonensis were randomly downloaded from NCBI databank. ESTs were analyzed and annotated using Blastx. The result showed that there were 60 ESTs had no match to any of the proteins and gene sequences in the published databases, and 695 ESTs score more than 80. According to the function, the identified 695 ESTs could be grouped into 13 categories related to metabolism, cellular development, immune evasion, host-parasite interactions, and so on. Among them, 65 (9.4%) were proteases and protease inhibitors, represented 19 potential proteases and protease inhibitors genes; 42 (6.0%) were allergens or antigens, represented 15 potential antigens/allergens genes. Signal P analysis was applied to the 19 putative proteases and protease inhibitors and the 15 antigens/allergens protein sequences to identify the potential signal peptides and anchors. The result demonstrated that there were ten putative proteins had N-terminal signal peptides and three had signal anchors, these putative excretory/secretory proteins might be the products of potential parasitism genes which played an important role in the adaptation of A. cantonensis to a parasitism life. These parasitism genes and proteins identified are expected to become potential targets for future research on anti-A. cantonensis drugs; moreover, the resulting genetic information is useful in elucidating the mechanisms of parasitism of A. cantonensis.
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