ArticleJournal of molecular neuroscience : MN2010
Interaction of Pax6 with SPARC and p53 in brain of mice indicates Smad3 dependent auto-regulation.
Article in Journal of molecular neuroscience : MN, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Autoregulation of Pax6 in neuronal cells is mediated by Pax6(5a), Pax6(ΔPD), SPARC, and p53.Molecular biology reports · 2022Article
- A Novel Mutation in Cse1l Disrupts Brain and Eye Development with Specific Effects on Pax6 Expression.Journal of developmental biology · 2021Article
- The genetic architecture of aniridia and Gillespie syndrome.Human genetics · 2019Review
- Article
- Investigating the mechanism by which SMAD3 induces PAX6 transcription to promote the development of non-small cell lung cancer.Respiratory research · 2018Article
- Co-Localization and Interaction of Pax5 with Iba1 in Brain of Mice.Cellular and molecular neurobiology · 2018Article
- Regulation of Apoptosis During Porcine Circovirus Type 2 Infection.Frontiers in microbiology · 2018Review
- Pax6 influences expression patterns of genes involved in neuro- degeneration.Annals of neurosciences · 2015Article
- ELISA based quantification of Pax6 expression in the developing Zebrafish embryos.Annals of neurosciences · 2015Article
- Pax6 interacts with SPARC and TGF-β in murine eyes.Molecular vision · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pax6 regulates formation of cerebral cortex, axon guidance, differentiation of neurons from glia and neuronal migration in the cerebellum. Although Pax6 is known to be a nuclear protein, it is presumed that it may interact with matricelluar proteins like SPARC during transport and processing of Pax6. The proteins involved in cell survival and cell proliferation can also not be ignored. The present study demonstrates co-localization of Pax6, secreted protein acidic rich in cysteine (SPARC), and p53 in astrocytes of primary culture, cerebellum and cortex region of mouse brain. The physical interaction of Pax6 with SPARC and p53 in brain of mice is also evident. The Pax6 probably participates with p53 to regulate neuronal survival. It indicates that the interaction of Pax6, SPARC and p53 may influence Smad3-dependent auto-regulation of Pax6.
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Registered trials
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