ArticleNeurochemical research2010
The fat-1 mouse has brain docosahexaenoic acid levels achievable through fish oil feeding.
Article in Neurochemical research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
- Dietary Intake of n-3 Polyunsaturated Fatty Acids Prior to a Mild Traumatic Brain Injury Demonstrates a Dose-Response Effect for Neuroprotective Benefits in Male C57BL/6 Mice.Current developments in nutrition · 2025Article
- Effects of Omega-3 Polyunsaturated Fatty Acids on the Formation of Adipokines, Cytokines, and Oxylipins in Retroperitoneal Adipose Tissue of Mice.International journal of molecular sciences · 2024Article
- Short-term dietary changes are reflected in the cerebral content of adult ring-billed gulls.Royal Society open science · 2024Article
- N-3 Polyunsaturated Fatty Acids Ameliorate Neurobehavioral Outcomes Post-Mild Traumatic Brain Injury in theNutrients · 2021Article
- Brain PUFA Concentrations Are Differentially Affected by Interactions of Diet, Sex, Brain Regions, and Phospholipid Pools in Mice.The Journal of nutrition · 2020Article
- Brain omega-3 polyunsaturated fatty acids modulate microglia cell number and morphology in response to intracerebroventricular amyloid-β 1-40 in mice.Journal of neuroinflammation · 2016Article
- Transgenic increase in n-3/n-6 fatty acid ratio protects against cognitive deficits induced by an immune challenge through decrease of neuroinflammation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- 17β-estradiol increases liver and serum docosahexaenoic acid in mice fed varying levels of α-linolenic acid.Lipids · 2014Article
- A protective lipidomic biosignature associated with a balanced omega-6/omega-3 ratio in fat-1 transgenic mice.PloS one · 2014Article
- Whole body synthesis rates of DHA from α-linolenic acid are greater than brain DHA accretion and uptake rates in adult rats.Journal of lipid research · 2014Article
- Investigating the role of polyunsaturated fatty acids in bone development using animal models.Molecules (Basel, Switzerland) · 2013Review
- Unesterified docosahexaenoic acid is protective in neuroinflammation.Journal of neurochemistry · 2013Article
- Article
- Omega-3 fatty acids induce apoptosis in human breast cancer cells and mouse mammary tissue through syndecan-1 inhibition of the MEK-Erk pathway.Carcinogenesis · 2011Article
- Transgenic conversion of omega-6 into omega-3 fatty acids in a mouse model of Parkinson's disease.Journal of lipid research · 2011Article
- Endogenous synthesis of n-3 polyunsaturated fatty acids in Fat-1 mice is associated with increased mammary gland and liver syndecan-1.PloS one · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Fat-1 transgenic mice endogenously convert n-6 to n-3 polyunsaturated fatty acids (PUFA). The aims of this study were to test whether a) fish oil feeding can attain similar brain n-3 PUFA levels as the fat-1 mouse, and b) fat-1 mouse brain docosahexaenoic acid (22:6n-3; DHA) levels can be potentiated by fish oil feeding. Fat-1 mice and their wildtype littermates consumed either a 10% safflower oil (SO) or a 2% fish oil and 8% safflower oil chow (FO). Brain total lipid and phospholipid fraction fatty acids were analyzed using GC-FID. Wildtype mice fed FO chow had similar brain levels of DHA as fat-1 mice fed SO chow. Fat-1 mice fed FO chow had similar brain n-3 PUFA levels as fat-1 mice fed SO chow. In conclusion, brain levels of DHA in the fat-1 mouse can be obtained by and were not further augmented with fish oil feeding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.