ArticleJournal of computational neuroscience2010
Computational modeling of GABAA receptor-mediated paired-pulse inhibition in the dentate gyrus.
Article in Journal of computational neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- Hippocampal network activity changes during early epileptogenesis predict subsequent epilepsy.Epilepsia · 2026Article
- Latent toxoplasmosis impairs learning and memory yet strengthens short-term and long-term hippocampal synaptic plasticity at perforant pathway-dentate gyrus, and Schaffer collatterals-CA1 synapses.Scientific reports · 2023Article
- Neuroligin-3 Regulates Excitatory Synaptic Transmission and EPSP-Spike Coupling in the Dentate Gyrus In Vivo.Molecular neurobiology · 2022Article
- Enhanced LTP of population spikes in the dentate gyrus of mice haploinsufficient for neurobeachin.Scientific reports · 2020Article
- Synaptic Plasticity and Excitation-Inhibition Balance in the Dentate Gyrus: Insights fromNeural plasticity · 2018Review
- Article
- Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit.eLife · 2016Article
- Astrocyte- neuron interaction as a mechanism responsible for generation of neural synchrony: a study based on modeling and experiments.Journal of computational neuroscience · 2013Article
- Toward a full-scale computational model of the rat dentate gyrus.Frontiers in neural circuits · 2012Article
- The role of collybistin in gephyrin clustering at inhibitory synapses: facts and open questions.Frontiers in cellular neuroscience · 2011Article
- Paired-pulse Inhibition and Disinhibition of the Dentate Gyrus Following Orexin Receptors Inactivation in the Basolateral Amygdala.Basic and clinical neuroscienceArticle
- Acute effect of cholecystokinin on short-term synaptic plasticity in the rat hippocampus.Research in pharmaceutical sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paired-pulse inhibition (PPI) of the population spike observed in extracellular field recordings is widely used as a read-out of hippocampal network inhibition. PPI reflects GABA(A) receptor-mediated inhibition of principal neurons through local interneurons. However, because of its polysynaptic nature, it is difficult to assign PPI changes to precise synaptic mechanisms. Here we used a detailed network model of the dentate gyrus to simulate PPI of granule cell action potentials and analyze its network properties. Our computational analysis indicates that PPI results mainly from a combination of perisomatic feed-forward and feedback inhibition of granule cells by basket cells. Feed-forward inhibition mediated by basket cells appeared to be the most significant source of PPI. Our simulations suggest that PPI depends more on somatic than on dendritic inhibition of granule cells. Furthermore, PPI was modulated by changes in GABA(A) reversal potential (E(GABA)) and by alterations in intrinsic excitability of granule cells. In summary, computer modeling provides a useful tool for determining the role of synaptic and intrinsic cellular mechanisms in paired-pulse field potential responses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.