ArticleInflammation2010
T-helper 1, T-helper 2, and T-regulatory cytokines gene polymorphisms in irritable bowel syndrome.
Article in Inflammation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Association of interleukin-10 polymorphisms with risk of irritable bowel syndrome: a meta-analysis.World journal of gastroenterology · 2013Pooled it
- Similar Symptoms, Distinct Syndromes: Multi-modal Approach to the Patient with an IBD-IBS Overlap.Digestive diseases and sciences · 2026Review
- Clinical Management of the Microbiome in Irritable Bowel Syndrome.Journal of the Canadian Association of Gastroenterology · 2021Article
- Effect of the interleukin 10 polymorphisms on interleukin 10 production and visceral hypersensitivity in Chinese patients with diarrhea-predominant irritable bowel syndrome.Chinese medical journal · 2019Article
- High-sensitive C-Reactive Protein as a Marker for Inflammation in Irritable Bowel Syndrome.Journal of clinical gastroenterology · 2016Article
- Molecular basis of the irritable bowel syndrome.World journal of gastroenterology · 2014Review
- Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome.American journal of physiology. Gastrointestinal and liver physiology · 2013Review
- Host immune response determines visceral hyperalgesia in a rat model of post-inflammatory irritable bowel syndrome.Journal of gastroenterology · 2013Article
- Investigation of interleukin-10 promoter polymorphisms and interleukin-10 levels in children with irritable bowel syndrome.Gut and liver · 2013Article
- Interleukin-8 and -10 gene polymorphisms in irritable bowel syndrome.Molecular biology reports · 2012Article
- Findings related to IL-8 and IL-10 gene polymorphisms in a Mexican patient population with irritable bowel syndrome infected with Blastocystis.Parasitology research · 2012Article
- Blastocystis infection is associated with irritable bowel syndrome in a Mexican patient population.Parasitology research · 2012Article
- The role of genetics in IBS.Gastroenterology clinics of North America · 2011Review
- Lack of Association between Interleukin 12 C(-1188)A Polymorphism and Irritable Bowel Syndrome.Avicenna journal of medical biotechnology · 2011Article
- Parasites in Mexican patients with irritable bowel syndrome: a case-control study.Parasites & vectors · 2010Article
- Irritable bowel syndrome: a review article.Middle East journal of digestive diseases · 2010Review
- Current insights into the innate immune system dysfunction in irritable bowel syndrome.Annals of gastroenterologyReview
- Interleukin 10 and Transforming Growth Factor Beta Polymorphisms as Risk Factors for Kawasaki Disease: A Case-Control Study and Meta-Analysis.Avicenna journal of medical biotechnologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammation and mucosal immune system activation have an important role in irritable bowel syndrome (IBS), whereas genetic factors can control some immunological mediators. In this study, a number of polymorphic genes coding for T-helper 1, T-helper 2, and T-regulatory cytokines were genotyped in 71 patients with IBS, and the results were compared with controls. IL-4 CC genotype at position -590, IL-4 TT genotype at position -33, and IL-10 GA genotype at position -1082 were significantly overrepresented in the patients with IBS in comparison with controls (P < 0.001). The frequencies of the following haplotypes in the patient group were significantly higher than in the control group: IL-2 (-330, +160) GT haplotype (P = 0.002), IL-4 (-1098, -590, -33) TCC haplotype (P < 0.001), and TCT haplotype (P < 0.001). While production of cytokines could be affected by genetic polymorphisms within coding and promoter regions of cytokine genes, IL-4 and IL-10 gene polymorphisms could affect individual susceptibility to IBS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.