Trial reportInternational journal of colorectal disease2010
Comparison of immunologic outcomes of laparoscopic vs open approaches in clinical stage III colorectal cancer.
Trial report in International journal of colorectal disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Pooled it
- Intestinal permeability, systemic endotoxemia, and bacterial translocation after open or laparoscopic resection for colon cancer: a prospective randomized study.International journal of colorectal disease · 2013Trial
- Differential effect of psoralidin in enhancing apoptosis of colon cancer cells via nuclear factor-κB and B-cell lymphoma-2/B-cell lymphoma-2-associated X protein signaling pathways.Oncology letters · 2016Article
- Laparoscopically assisted colorectal surgery provides better short-term clinical and inflammatory outcomes compared to open colorectal surgery.Archives of medical science : AMS · 2015Article
- Efficacy and safety of laparoscopic surgery in elderly patients with colorectal cancer.Molecular and clinical oncology · 2015Article
- Surgical stress response after colorectal resection: a comparison of robotic, laparoscopic, and open surgery.Techniques in coloproctology · 2015Article
- Comparison of long-term oncologic outcomes of stage III colorectal cancer following laparoscopic versus open surgery.Annals of surgical treatment and research · 2015Article
- Immune response after laparoscopic colectomy for cancer: a review.Gastroenterology report · 2013Article
- Recovery of immunological homeostasis positively correlates both with early stages of right-colorectal cancer and laparoscopic surgery.PloS one · 2013Article
- Laparoscopic and open splenectomy for splenomegaly secondary to liver cirrhosis: an evaluation of immunity.Surgical endoscopy · 2012Article
- Influence of surgical manipulation and surgical modality on the molecular detection of circulating tumor cells from colorectal cancer.Journal of the Korean Surgical Society · 2012Article
- A single surgeon's experience with 54 consecutive cases of multivisceral resection for locally advanced primary colorectal cancer: can the laparoscopic approach be performed safely?Surgical endoscopy · 2012Article
- Laparoscopic and open resection for colorectal cancer: an evaluation of cellular immunity.BMC gastroenterology · 2010Article
- Effects of low and standard intra-abdominal pressure on systemic inflammation and immune response in laparoscopic adrenalectomy: A prospective randomised study.Journal of minimal access surgeryArticle
- Gut barrier function and systemic endotoxemia after laparotomy or laparoscopic resection for colon cancer: A prospective randomized study.Journal of minimal access surgeryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeImproved survival in patients with stage III colon cancer after a laparoscopic colectomy (LC) has been reported by Lacy et al. (Lancet 359:2224-2229, 6), and preserved immunity was suggested as the reason for the survival advantage. The aim of our study was to clarify the existence of an immunological benefit after laparoscopic colon cancer surgery (LC) compared to open colon surgery (OC).
methodsFrom January 2006 to November 2007, 74 patients with clinical stage III colon cancer were prospectively assigned to undergo a LC (n = 35) or an OC (n = 39). The immune factors were examined preoperatively, and on the first and fifth days postoperatively (POD1 and POD5).
resultsThe cellular immune factors were significantly decreased; however, there was no significant difference between the LC and OC groups except for the mHLA-DR. The LC group had a better preserved mHLA-DR on POD5 than did the OC group (p = 0.015), in addition to a faster recovery (p < 0.005).
conclusionThe mHLA-DR on POD5 was affected less by the LC compared to the OC. The LC demonstrated minimal immunological advantage when compared to the OC. However, further study is required to clarify the immunological benefits of the LC on colorectal cancer prognosis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.