ArticleWorld journal of surgery2010
Deep venous thrombosis after surgery for inflammatory bowel disease: is standard dose low molecular weight heparin prophylaxis enough?
Article in World journal of surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Preoperative optimization of patients with inflammatory bowel disease undergoing gastrointestinal surgery: a systematic review.International journal of colorectal disease · 2017Pooled it
- Preoperative Optimization of Crohn's Patients before Abdominopelvic Surgery.Clinics in colon and rectal surgery · 2025Review
- Inflammatory Bowel Disease and Neurodegenerative Diseases.Gut and liver · 2023Review
- A postdischarge venous thromboembolism risk calculator for inflammatory bowel disease surgery.Surgery · 2021Article
- The incidence and risk factors of venous thromboembolism in Japanese inpatients with inflammatory bowel disease: a retrospective cohort study.Intestinal research · 2018Article
- The effect of pre-operative optimization on post-operative outcome in Crohn's disease resections.International journal of colorectal disease · 2017Article
- Renal and Gastrointestinal Considerations in Joint Replacement Surgery.Journal of nature and science · 2015Article
- Colectomy is a risk factor for venous thromboembolism in ulcerative colitis.World journal of gastroenterology · 2015Observational
- Inflammatory bowel disease and thromboembolism.World journal of gastroenterology · 2014Review
- Venous thrombosis and prothrombotic factors in inflammatory bowel disease.World journal of gastroenterology · 2014Review
- Venous thromboembolism in patients with inflammatory bowel diseases: a case-control study of risk factors.Inflammatory bowel diseases · 2014Article
- Venous thromboembolism in patients with inflammatory bowel disease: focus on prevention and treatment.World journal of gastroenterology · 2014Review
- Preoperative optimization of crohn disease.Clinics in colon and rectal surgery · 2013Review
- IBD: postoperative VTE prophylaxis in IBD.Nature reviews. Gastroenterology & hepatology · 2013Article
- Inflammatory bowel disease: perioperative pharmacological considerations.Mayo Clinic proceedings · 2011Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInflammatory bowel disease (IBD) and colorectal surgery are risk factors for deep venous thrombosis (DVT). The aim of this prospective study was to evaluate the effectiveness of standardized prophylactic low molecular weight heparin (LMWH) therapy in patients who underwent surgery for ulcerative colitis (UC) and Crohn's disease (CD). PATIENTS AND
methodsSince 1999 all patients operated on for colorectal diseases in our institute have received 4,000 IU/day LMWH from the day of operation to discharge. The complete series of patients who had major colorectal surgery from 1999 until 2006 were reviewed for overt DVT episodes. Furthermore, 60 consecutive patients who were admitted for surgery for IBD were prospectively enrolled in the 2004-2006 period. Each patient underwent venous color Doppler ultrasound scan at admission and at discharge. Demographic data, disease activity, and clotting parameters were collected. Data were analyzed with Spearman's correlation test, multiple regression, and receiver operating characteristics (ROC) curves analysis.
resultsThe rate of DVT in UC patients was significantly higher than in colorectal cancer patients (p = 0.009), and the odds ratio (OR) for postoperative DVT in UC patients was 7.4 (95% CI 1.4-44.4; p = 0.017). Female gender, UC diagnosis, active rectal bleeding, aPTT value, aCL IgM, abeta2 IgM, and pANCA levels significantly correlated with postoperative DVT. At multivariate analysis only aCL IgM levels were found to be independently associated with postoperative DVT (p = 0.05).
conclusionsIn conclusion, our study showed that prophylactic therapy with 4,000 IU/day LMWH was not completely effective for the prevention of postoperative DVT in patients with CD, and even less so in those with UC. In these patients, a more tailored prophylactic therapy should be considered, and further randomized controlled trials testing the effectiveness of different prophylactic protocols would be advisable. Furthermore, aCL IgM serum levels might be helpful in identifying IBD patients who are at higher risk of postoperative DVT.
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