ArticleJournal of molecular medicine (Berlin, Germany)2010
Obesity-dependent association of TNF-LTA locus with type 2 diabetes in North Indians.
Article in Journal of molecular medicine (Berlin, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- The TNF-alpha -308G/A polymorphism is associated with type 2 diabetes mellitus: an updated meta-analysis.Molecular biology reports · 2014Pooled it
- Common variants of homocysteine metabolism pathway genes and risk of type 2 diabetes and related traits in Indians.Experimental diabetes research · 2012Pooled it
- Associations of tumor necrosis factor alpha genetic variants with metabolic syndrome and type 2 diabetes mellitus in a Thai population.PloS one · 2026Article
- Genes of cancer-related fatigue: a scoping review.Frontiers in oncology · 2024Article
- Pharmacogenomics and Personalized Medicine in Type 2 Diabetes Mellitus: Potential Implications for Clinical Practice.Pharmacogenomics and personalized medicine · 2021Review
- Genetic Variability in Antioxidative and Inflammatory Pathways Modifies the Risk for PCOS and Influences Metabolic Profile of the Syndrome.Metabolites · 2020Article
- Serum profile of cytokines and their genetic variants in metabolic syndrome and healthy subjects: a comparative study.Bioscience reports · 2019Article
- Genetics of obesity and its measures in India.Journal of genetics · 2018Review
- Expression and Sequence Variants of Inflammatory Genes; Effects on Plasma Inflammation Biomarkers Following a 6-Week Supplementation with Fish Oil.International journal of molecular sciences · 2016Article
- Cytokine gene associations with self-report ratings of morning and evening fatigue in oncology patients and their family caregivers.Biological research for nursing · 2015Article
- DNA methylation mediates the impact of exposure to prenatal maternal stress on BMI and central adiposity in children at age 13½ years: Project Ice Storm.Epigenetics · 2015Article
- Lymphotoxin organizes contributions to host defense and metabolic illness from innate lymphoid cells.Cytokine & growth factor reviews · 2014Review
- Structure of tumor necrosis factor-alpha haploblocks in European populations.Immunogenetics · 2013Article
- Linking the microbiota and metabolic disease with lymphotoxin.International immunology · 2013Review
- Lymphotoxin signalling in immune homeostasis and the control of microorganisms.Nature reviews. Immunology · 2013Review
- Securing the border: lymphotoxin, IL-23 and IL-22 keep out the bad guys and 'fatten' the homeland.Nature immunology · 2012Article
- Lymphotoxin regulates commensal responses to enable diet-induced obesity.Nature immunology · 2012Article
- Deficiency of lymphotoxin-α does not exacerbate high-fat diet-induced obesity but does enhance inflammation in mice.American journal of physiology. Endocrinology and metabolism · 2012Article
- No association of TNFRSF1B variants with type 2 diabetes in Indians of Indo-European origin.BMC medical genetics · 2011Article
- Common variants in CRP and LEPR influence high sensitivity C-reactive protein levels in North Indians.PloS one · 2011Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Six common genetic variants (rs2229094, rs1041981, rs1800630, rs1800629, rs361525, and rs1800610) in the TNF-LTA locus encoding the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and lymphotoxin-alpha have been shown to be associated with various metabolic traits including susceptibility to type 2 diabetes, metabolic syndrome, insulin resistance, and increased body mass index (BMI) in Caucasians from different geographic locations and have yielded mixed results. We tested for the association of these variants with type 2 diabetes in North Indians by studying 2,115 participants comprising of 1,073 type 2 diabetes patients and 1,042 controls. We report the association of a promoter region variant of TNF: rs1800630 and non-synonymous LTA variant: rs2229094 with type 2 diabetes [OR = 0.83 (95% CI 0.72-0.95), P = 0.005 and OR = 0.86 (95% CI 0.75-0.98), P = 0.02, respectively]. Although these associations were BMI-dependent, no interactive effect of BMI and variants on type 2 diabetes was detectable. Further, the haplotype carrying all the six major alleles conferred susceptibility to type 2 diabetes [OR = 1.23 (95% CI 1.06-1.42), P = 0.005; P (permuted) = 0.02], with the effect much enhanced in non-obese subjects [OR = 1.45 (95% CI 1.19-1.78), P = 2 x 10(-4): P (permuted) = 3 x 10(-4)]. The minor allele of rs2229094 was associated with lower hsCRP, BMI, and waist circumference (WC), while the minor allele of rs1800630 showed association with lower BMI and WC (all P < 0.01). This is the first report demonstrating association of rs1800630 and rs2229094 with type 2 diabetes in any population, suggesting an important role of the TNF-LTA locus in type 2 diabetes in North Indians.
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