ReviewMolecular psychiatry2010
Rett syndrome and other autism spectrum disorders--brain diseases of immune malfunction?
Review in Molecular psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 51 citations in OpenAlex.
- When Neurodevelopment Meets Autoimmunity: Pemphigus Foliaceus in Rett Syndrome Expands the Clinical Spectrum-A Case Report.International journal of molecular sciences · 2026Article
- Immunomodulation of behavior impairment via spleen-specific targeting lipid nanoparticles in a MeCP2 transgenic mouse model.Scientific reports · 2025Article
- Methyl-CpG-Binding Protein 2 Emerges as a Central Player in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders.Cellular and molecular neurobiology · 2023Review
- MeCP2 deficiency exacerbates the neuroinflammatory setting and autoreactive response during an autoimmune challenge.Scientific reports · 2021Article
- Social Interaction Test in Home Cage as a Novel and Ethological Measure of Social Behavior in Mice.Experimental neurobiology · 2019Article
- Functional and Mechanistic Neurotoxicity Profiling Using Human iPSC-Derived Neural 3D Cultures.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- Beyond infection - Maternal immune activation by environmental factors, microglial development, and relevance for autism spectrum disorders.Experimental neurology · 2018Review
- Neonatal infection produces significant changes in immune function with no associated learning deficits in juvenile rats.Developmental neurobiology · 2017Article
- The Immune System, Cytokines, and Biomarkers in Autism Spectrum Disorder.Neuroscience bulletin · 2017Review
- Inflammatory protein response in CDKL5-Rett syndrome: evidence of a subclinical smouldering inflammation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017Article
- Oxygen exchange and energy metabolism in erythrocytes of Rett syndrome and their relationships with respiratory alterations.Molecular and cellular biochemistry · 2017Article
- Persistent Unresolved Inflammation in theMediators of inflammation · 2017Article
- A review of Rett syndrome (RTT) with induced pluripotent stem cells.Stem cell investigation · 2016Review
- Immune deficiency influences juvenile social behavior and maternal behavior.Behavioral neuroscience · 2015Article
- Cytokine Dysregulation in MECP2- and CDKL5-Related Rett Syndrome: Relationships with Aberrant Redox Homeostasis, Inflammation, and ω-3 PUFAs.Oxidative medicine and cellular longevity · 2015Article
- A model for the induction of autism in the ecosystem of the human body: the anatomy of a modern pandemic?Microbial ecology in health and disease · 2015Article
- Maternal immune activation leads to activated inflammatory macrophages in offspring.Brain, behavior, and immunity · 2014Article
- Immune dysfunction in Rett syndrome patients revealed by high levels of serum anti-N(Glc) IgM antibody fraction.Journal of immunology research · 2014Article
- Inflammatory lung disease in Rett syndrome.Mediators of inflammation · 2014Article
- Inflammatory macrophage phenotype in BTBR T+tf/J mice.Frontiers in neuroscience · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Neuroimmunology was once referred to in terms of its pathological connotation only and was generally understood as covering the deleterious involvement of the immune system in various diseases and disorders of the central nervous system (CNS). However, our conception of the function of the immune system in the structure, function, and plasticity of the CNS has undergone a sea change after relevant discoveries over the past two decades, and continues to be challenged by more recent studies of neurodevelopment and cognition. This review summarizes the recent advances in understanding of immune-system participation in the development and functioning of the CNS under physiological conditions. Considering as an example Rett syndrome a devastating neurodevelopmental disease, we offer a hypothesis that might help to explain the part played by immune cells in its etiology, and hence suggests that the immune system might be a feasible therapeutic target for alleviation of some of the symptoms of this and other autism spectrum disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.