Evidence map›Paper›PMID 20177395›Full record

ReviewNature reviews. Molecular cell biology2010

Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis.

Mary Ellen Moynahan, Maria Jasin

Abstract readReview
In one paragraph

Review in Nature reviews. Molecular cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 589 papers.

0numbers the graph read from it
0cells of the map it votes in
589citing papers in PubMed
31.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

589 citing papers in PubMed, 914 citations in OpenAlex.

  1. Article
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  3. Review
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  6. RSF1-Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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529 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Mary Ellen MoynahanDevelopmental Biology Program, New York, New York 10065, USA.
Maria Jasin
Arthur Ashe Learning Center · US

Funding

The Role of Id Proteins in Breast TumorigenesisP01CA094060 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI NORTON, LARRY · 2002 to 2018
$39.4M
RADIATION RESISTANT AND SENSITIVE CELLS DNA BREAK REPAIRR01GM054668 · NIGMS · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI JASIN, MARIA · 1998 to 2015
$5.3M
NCI NIH HHS P01 CA094060NCI NIH HHS P01CA94060NIGMS NIH HHS R01 GM054668NIGMS NIH HHS R01GM54668
6 · The paper itself

Abstract

Mitotic homologous recombination promotes genome stability through the precise repair of DNA double-strand breaks and other lesions that are encountered during normal cellular metabolism and from exogenous insults. As a result, homologous recombination repair is essential during proliferative stages in development and during somatic cell renewal in adults to protect against cell death and mutagenic outcomes from DNA damage. Mutations in mammalian genes encoding homologous recombination proteins, including BRCA1, BRCA2 and PALB2, are associated with developmental abnormalities and tumorigenesis. Recent advances have provided a clearer understanding of the connections between these proteins and of the key steps of homologous recombination and DNA strand exchange.

Indexed as

Genomic InstabilityAnimalsDNA Breaks, Double-StrandedDNA Breaks, Single-StrandedDNA RepairHumansMitosisModels, BiologicalNeoplasmsRecombination, Genetic

Identifiers

PMID20177395
PMCPMC3261768
OpenAlexW2071411482

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.