ArticleObstetrics and gynecology2010
Pharmacogenomics of maternal tobacco use: metabolic gene polymorphisms and risk of adverse pregnancy outcomes.
Article in Obstetrics and gynecology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Maternal nicotine metabolism moderates the impact of maternal cigarette smoking on infant birth weight: A Collaborative Perinatal Project investigation.Drug and alcohol dependence · 2022Article
- Maternal and early life exposures and their potential to influence development of the microbiome.Genome medicine · 2022Review
- Gene-environment interactions related to maternal exposure to environmental and lifestyle-related chemicals during pregnancy and the resulting adverse fetal growth: a review.Environmental health and preventive medicine · 2022Review
- Interactions between Environmental Exposures and the Microbiome: Implications for Fetal Programming.Current opinion in endocrine and metabolic research · 2020Article
- Mitochondrial toxicity of tobacco smoke and air pollution.Toxicology · 2017Review
- Tobacco, e-cigarettes, and child health.Current opinion in pediatrics · 2017Review
- A qualitative assessment of the perceived risks of electronic cigarette and hookah use in pregnancy.BMC public health · 2015Article
- Is there evidence for potential harm of electronic cigarette use in pregnancy?Birth defects research. Part A, Clinical and molecular teratology · 2015Review
- Genetic modification of the effect of maternal household air pollution exposure on birth weight in Guatemalan newborns.Reproductive toxicology (Elmsford, N.Y.) · 2014Article
- Pharmacogenetics and individualizing drug treatment during pregnancy.Pharmacogenomics · 2014Review
- Association of maternal CNVs in GSTT1/GSTT2 with smoking, preterm delivery, and low birth weight.Frontiers in genetics · 2013Article
- Maternal smoking as a model for environmental epigenetic changes affecting birthweight and fetal programming.Molecular human reproduction · 2013Review
- Smaller fetal size in singletons after infertility therapies: the influence of technology and the underlying infertility.Fertility and sterility · 2011Article
- Maternal tobacco use modestly alters correlated epigenome-wide placental DNA methylation and gene expression.Epigenetics · 2011Article
- Maternal tobacco use is associated with increased markers of oxidative stress in the placenta.American journal of obstetrics and gynecology · 2011Article
- Polymorphisms in maternal and fetal genes encoding for proteins involved in extracellular matrix metabolism alter the risk for small-for-gestational-age.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2011Article
- Genetic and epigenetic influences associated with intrauterine growth restriction due to in utero tobacco exposure.Pediatric endocrinology reviews : PER · 2010Review
Corrections and comments
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Authors and funding
15 authors at 14 institutions in 1 country.
Funding
Abstract
objectiveTo assess whether functional maternal or fetal genotypes along well-characterized metabolic pathways (ie, CYP1A1, GSTT1, and CYP2A6) may account for varying associations with adverse outcomes among pregnant women who smoke.
methodsDNA samples from 502 smokers and their conceptuses, alongside women in a control group, were genotyped for known functional allelic variants of CYP1A1 (Ile462Val AA>AG/GG), GSTT1(del), and CYP2A6 (Lys160His T>A). Modification of the association between smoking and outcome by genotype was evaluated. Outcomes included birth weight, pregnancy loss, preterm birth, small for gestational age, and a composite outcome composed of the latter four components plus abruption.
resultsNo interaction between maternal or fetal genotype of any of the polymorphisms and smoking could be demonstrated. In contrast, the association of smoking with gestational age-adjusted birth weight (birth weight ratio) was modified by fetal GSTT1 genotype (P for interaction=.02). Fetuses with GSTT1(del) had a mean birth weight reduction among smokers of 262 g (P=.01), whereas in fetuses without the GSTT1(del) the effect of tobacco exposure was nonsignificant (mean reduction 87 g, P=.16). After adjusting for confounding, results were similar.
conclusionFetal GSTT1 deletion significantly and specifically modifies the effect of smoking on gestational age-corrected birth weight.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.