ArticleObstetrics and gynecology2010
Effect of pregnancy on maternal asthma symptoms and medication use.
Article in Obstetrics and gynecology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.
- Risk factors for asthma exacerbations during pregnancy: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2022Pooled it
- How Pregnancy Affects Asthma in Korea: Risk Factors and Adherence Decline.Allergy, asthma & immunology research · 2026Article
- Why Every Asthma Patient Tells a Different Story.Journal of clinical medicine · 2025Article
- Reconsidering Gender in Asthma: Is It All About Sex? A Perspective Review.Journal of clinical medicine · 2025Article
- Asthma Exacerbation Risk in Pregnancy and Postpartum: Assessing the Impact of Gestational Diabetes Mellitus and Other Key Factors.The journal of allergy and clinical immunology. In practice · 2025Article
- Incidence of New Asthma in Pregnancy and Associated Risk Factors: A 10-Year Nationwide Population-Based Study.Allergy, asthma & immunology research · 2024Article
- The Association of Periconception Asthma Medication Discontinuation with Adverse Obstetric Outcomes.American journal of perinatology · 2024Article
- Treatable Traits in Pregnant Women with Asthma.Respiration; international review of thoracic diseases · 2024Review
- Asthma in pregnancy.Allergy and asthma proceedings · 2023Review
- Asthma Medication Regimens in Pregnancy: Longitudinal Changes in Asthma Status.American journal of perinatology · 2023Article
- Risk factors for asthma exacerbation during pregnancy: protocol for a systematic review and meta-analysis.Systematic reviews · 2022Article
- Determining the Clinical Course of Asthma in Pregnancy.The journal of allergy and clinical immunology. In practice · 2022Article
- The Role of Comorbidities in Difficult-to-Control Asthma in Adults and Children.The journal of allergy and clinical immunology. In practice · 2022Article
- Sex Disparities in Asthma Development and Clinical Outcomes: Implications for Treatment Strategies.Journal of asthma and allergy · 2022Review
- Sex and gender in asthma.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- Sex, Cells, and Asthma.Mayo Clinic proceedings · 2021Review
- Knowledge, Attitudes, Beliefs, and Treatment Burden Related to the Use of Levothyroxine in Hypothyroid Pregnant Women in the United States.Thyroid : official journal of the American Thyroid Association · 2021Article
- Repeated allergic asthma in early versus late pregnancy differentially impacts offspring brain and behavior development.Brain, behavior, and immunity · 2021Article
- Estrogen receptor-α signaling increases allergen-induced IL-33 release and airway inflammation.Allergy · 2021Article
- Medicines prescribed for asthma, discontinuation and perinatal outcomes, including breastfeeding: A population cohort analysis.PloS one · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo examine whether factors related to the patient or her treatment influence asthma severity during pregnancy.
methodsSymptom and medication data were collected by in-person and telephone interviews. Women were recruited before 24 weeks of gestation through private obstetricians and hospital clinics. Eight hundred seventy-two women had physician-diagnosed asthma, 686 were active asthmatics, and 641 with complete data were analyzed. The Global Initiative for Asthma measured severity. Cumulative logistic regression models for repeated measures assessed changes in asthma severity during each month of pregnancy.
resultsTwo factors had significant and profound effects on the course of asthma: prepregnancy severity and use of medication according to Global Initiative for Asthma guidelines. Although several factors were analyzed (race, age, atopic status, body mass index, parity, fetal sex, and smoking), none were significant risk factors for changes in asthma severity, measured in a clinically important way as a one-step change in Global Initiative for Asthma category. Women with milder asthma received most benefit from appropriate treatment, 62% decreased risk for worsening asthma among those with intermittent asthma (0.38, 95% confidence interval 0.23-0.64) and 52% decreased risk among those with mild persistent asthma (odds ratio 0.48, 95% confidence interval 0.28-0.84). Month or trimester of gestation was not consistently associated with changes in asthma severity.
conclusionAsthma severity during pregnancy is similar to severity in the year before pregnancy, provided patients continue to use their prescribed medication. If women discontinue medication, even mild asthma is likely to become significantly more severe.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.