ArticleThe Journal of biological chemistry2010
Identification of Myb-binding protein 1A (MYBBP1A) as a novel substrate for aurora B kinase.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- Lymphoid Organ Proteomes Identify Therapeutic Efficacy Biomarkers Following the Intracavitary Administration of Curcumin in a Highly Invasive Rat Model of Peritoneal Mesothelioma.International journal of molecular sciences · 2021Article
- p38-MAPK-mediated translation regulation during early blastocyst development is required for primitive endoderm differentiation in mice.Communications biology · 2021Article
- The Tumor Suppressor Roles of MYBBP1A, a Major Contributor to Metabolism Plasticity and Stemness.Cancers · 2020Review
- Post-Translational Modifications of the Mini-Chromosome Maintenance Proteins in DNA Replication.Genes · 2019Review
- MYB - A regulatory factor in hematopoiesis.Gene · 2018Review
- Cytotoxic Effects of 24-Methylenecyloartanyl Ferulate on A549 Nonsmall Cell Lung Cancer Cells through MYBBP1A Up-Regulation and AKT and Aurora B Kinase Inhibition.Journal of agricultural and food chemistry · 2018Article
- Review
- The protein-interaction network with functional roles in tumorigenesis, neurodegeneration, and aging.Molecular and cellular biochemistry · 2016Review
- Myb-binding protein 1a (Mybbp1a) regulates levels and processing of pre-ribosomal RNA.The Journal of biological chemistry · 2012Article
- Epigeneitc silencing of ribosomal RNA genes by Mybbp1a.Journal of biomedical science · 2012Article
- Development of a chemical genetic approach for human aurora B kinase identifies novel substrates of the chromosomal passenger complex.Molecular & cellular proteomics : MCP · 2012Article
- Epigenetic silencing of myogenic gene program by Myb-binding protein 1a suppresses myogenesis.The EMBO journal · 2012Article
- Opposing function of MYBBP1A in proliferation and migration of head and neck squamous cell carcinoma cells.BMC cancer · 2012Article
- Article
- The transcription factor YY1 is a novel substrate for Aurora B kinase at G2/M transition of the cell cycle.PloS one · 2012Article
- WSTF does it all: a multifunctional protein in transcription, repair, and replication.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2011Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aurora kinases are mitotic enzymes involved in centrosome maturation and separation, spindle assembly and stability, and chromosome condensation, segregation, and cytokinesis and represent well known targets for cancer therapy because their deregulation has been linked to tumorigenesis. The availability of suitable markers is of crucial importance to investigate the functions of Auroras and monitor kinase inhibition in in vivo models and in clinical trials. Extending the knowledge on Aurora substrates could help to better understand their biology and could be a source for clinical biomarkers. Using biochemical, mass spectrometric, and cellular approaches, we identified MYBBP1A as a novel Aurora B substrate and serine 1303 as the major phosphorylation site. MYBBP1A is phosphorylated in nocodazole-arrested cells and is dephosphorylated upon Aurora B silencing or by treatment with Danusertib, a small molecule inhibitor of Aurora kinases. Furthermore, we show that MYBBP1A depletion by RNA interference causes mitotic progression delay and spindle assembly defects. MYBBP1A has until now been described as a nucleolar protein, mainly involved in transcriptional regulation. The results presented herein show MYBBP1A as a novel Aurora B kinase substrate and reveal a not yet recognized link of this nucleolar protein to mitosis.
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Registered trials
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