ArticleGenetics2010
Caenorhabditis elegans TRPV channels function in a modality-specific pathway to regulate response to aberrant sensory signaling.
Article in Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Wild strains reveal natural variation in C. elegans avoidance behaviors.G3 (Bethesda, Md.) · 2025Article
- Chemosensory adaptations inBiology letters · 2025Article
- Flavonoids as Signals Mediate Plant-nematode Communication Through Regulating Nematode Perceptual Ability.Journal of chemical ecology · 2025Article
- Sensory stimuli and cilium trafficking defects trigger the release of ciliary extracellular vesicles from multiple ciliary locations.bioRxiv : the preprint server for biology · 2025Article
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- Phosphodiesterases RegulatemicroPublication biology · 2025Article
- Cilia structure and intraflagellar transport differentially regulate sensory response dynamics within and between C. elegans chemosensory neurons.PLoS biology · 2024Article
- Unveiling the hidden world: How arbuscular mycorrhizal fungi and its regulated core fungi modify the composition and metabolism of soybean rhizosphere microbiome.Environmental microbiome · 2024Article
- The Caenorhabditis elegans innexin INX-20 regulates nociceptive behavioral sensitivity.Genetics · 2023Article
- Chemosensory signal transduction in Caenorhabditis elegans.Genetics · 2021Review
- ThemicroPublication biology · 2020Article
- SRD-1 in AWA neurons is the receptor for female volatile sex pheromones inEMBO reports · 2019Article
- G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 inThe Journal of biological chemistry · 2017Article
- Acid-sensing ion channel 2 (ASIC2) is selectively localized in the cilia of the non-sensory olfactory epithelium of adult zebrafish.Histochemistry and cell biology · 2015Article
- The C. elegans cGMP-dependent protein kinase EGL-4 regulates nociceptive behavioral sensitivity.PLoS genetics · 2013Article
- Circadian regulation of olfaction and an evolutionarily conserved, nontranscriptional marker in Caenorhabditis elegans.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Structural domains required for Caenorhabditis elegans G protein-coupled receptor kinase 2 (GRK-2) function in vivo.The Journal of biological chemistry · 2012Article
- Article
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Olfaction and some forms of taste (including bitter) are mediated by G protein-coupled signal transduction pathways. Olfactory and gustatory ligands bind to chemosensory G protein-coupled receptors (GPCRs) in specialized sensory cells to activate intracellular signal transduction cascades. G protein-coupled receptor kinases (GRKs) are negative regulators of signaling that specifically phosphorylate activated GPCRs to terminate signaling. Although loss of GRK function usually results in enhanced cellular signaling, Caenorhabditis elegans lacking GRK-2 function are not hypersensitive to chemosensory stimuli. Instead, grk-2 mutant animals do not chemotax toward attractive olfactory stimuli or avoid aversive tastes and smells. We show here that loss-of-function mutations in the transient receptor potential vanilloid (TRPV) channels OSM-9 and OCR-2 selectively restore grk-2 behavioral avoidance of bitter tastants, revealing modality-specific mechanisms for TRPV channel function in the regulation of C. elegans chemosensation. Additionally, a single amino acid point mutation in OCR-2 that disrupts TRPV channel-mediated gene expression, but does not decrease channel function in chemosensory primary signal transduction, also restores grk-2 bitter taste avoidance. Thus, loss of GRK-2 function may lead to changes in gene expression, via OSM-9/OCR-2, to selectively alter the levels of signaling components that transduce or regulate bitter taste responses. Our results suggest a novel mechanism and multiple modality-specific pathways that sensory cells employ in response to aberrant signal transduction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.