ArticleProceedings of the National Academy of Sciences of the United States of America2010
Multiple translational products from a five-nucleotide ribozyme.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
81 citing papers in PubMed, 155 citations in OpenAlex.
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- Yield and fidelity of early steps of ribosome-free translation depend on the RNA anchoring.Nucleic acids research · 2026Article
- Complex and Messy Prebiotic Chemistry: Obstacles and Opportunities for an RNA World.Life (Basel, Switzerland) · 2026Review
- Amino acids catalyse RNA formation under ambient alkaline conditions.Nature communications · 2025Article
- Traces of a Primitive RNA Ring in Current Genomes.Biology · 2025Article
- Selection-diversification interplay in oligonucleotide chemical evolution.Biophysics and physicobiology · 2025Article
- Intellectual frameworks to understand complex biochemical systems at the origin of life.Nature chemistry · 2025Article
- An anticodon-sensing T-boxzyme generates the elongator nonproteinogenic aminoacyl-tRNA in situ of a custom-made translation system for incorporation.Nucleic acids research · 2024Article
- Theoretical perspective on synthetic man-made life: Learning from the origin of life.Quantitative biology (Beijing, China) · 2023Review
- Transcriptional control of carbohydrate catabolism by the CcpA protein in the ruminal bacteriumApplied and environmental microbiology · 2023Article
- On the origin of life: an RNA-focused synthesis and narrative.RNA (New York, N.Y.) · 2023Article
- Mixed anhydrides at the intersection between peptide and RNA autocatalytic sets: evolution of biological coding.Interface focus · 2023Article
- RNA ligase ribozymes with a small catalytic core.Scientific reports · 2023Article
- Coevolution of reproducers and replicators at the origin of life and the conditions for the origin of genomes.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Enzyme-Free Copying of 12 Bases of RNA with Dinucleotides.Angewandte Chemie (International ed. in English) · 2022Article
- Article
- Genome Evolution from Random Ligation of RNAs of Autocatalytic Sets.International journal of molecular sciences · 2021Article
- Single nucleotide translation without ribosomes.Nature chemistry · 2021Article
- Single-round deoxyribozyme discovery.Nucleic acids research · 2021Article
- Origin of Species before Origin of Life: The Role of Speciation in Chemical Evolution.Life (Basel, Switzerland) · 2021Review
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
An indispensable step in protein biosynthesis is the 2(')(3(')) aminoacylation of tRNA by aminoacyl-tRNA synthetases. Here we show that a similar activity exists in a tiny, 5-nt-long RNA enzyme with a 3-nt active center. The small ribozyme initially trans-phenylalanylates a partially complementary 4-nt RNA selectively at its terminal 2(')-ribose hydroxyl using PheAMP, the natural form for activated amino acid. The initial 2(') Phe-RNA product can be elaborated into multiple peptidyl-RNAs. Reactions do not require divalent cations, and have limited dependence on monovalent cations. Small size and minimal requirements for regiospecific translational activity strongly support the hypothesis that minuscule RNA enzymes participated in early forms of translation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.