ArticleThe Journal of cell biology2010
Notch ligand activity is modulated by glycosphingolipid membrane composition in Drosophila melanogaster.
Article in The Journal of cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 53 citations in OpenAlex.
- Article
- Hepatic ceramide synthesis links systemic inflammation to organelle dysfunction in cancer.bioRxiv : the preprint server for biology · 2025Article
- Toll-like receptors as a missing link in Notch signaling cascade during neurodevelopment.Frontiers in molecular neuroscience · 2024Article
- Phosphatidic acid increases Notch signalling by affecting Sanpodo trafficking during Drosophila sensory organ development.Scientific reports · 2020Article
- Functional analysis of glycosylation using Drosophila melanogaster.Glycoconjugate journal · 2020Review
- The glycosphingolipid MacCer promotes synaptic bouton formation in Drosophila by interacting with Wnt.eLife · 2018Article
- Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.The EMBO journal · 2017Article
- Sara phosphorylation state controls the dispatch of endosomes from the central spindle during asymmetric division.Nature communications · 2017Article
- Glycosphingolipid-Protein Interaction in Signal Transduction.International journal of molecular sciences · 2016Review
- Sphingolipids, Transcription Factors, and Conserved Toolkit Genes: Developmental Plasticity in the Ant Cardiocondyla obscurior.Molecular biology and evolution · 2015Article
- Article
- Structural analysis uncovers lipid-binding properties of Notch ligands.Cell reports · 2013Article
- Disruption of Drosophila melanogaster lipid metabolism genes causes tissue overgrowth associated with altered developmental signaling.PLoS genetics · 2013Article
- Ubiquitinations in the notch signaling pathway.International journal of molecular sciences · 2013Article
- A glycosphingolipid binding domain controls trafficking and activity of the mammalian notch ligand delta-like 1.PloS one · 2013Article
- Article
- Multiscale modeling of the causal functional roles of nsSNPs in a genome-wide association study: application to hypoxia.BMC genomics · 2013Article
- Neurofibromatosis-like phenotype in Drosophila caused by lack of glucosylceramide extension.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.The Journal of cell biology · 2011Article
- Notch ligand ubiquitylation: what is it good for?Developmental cell · 2011Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endocytosis of the transmembrane ligands Delta (Dl) and Serrate (Ser) is required for the proper activation of Notch receptors. The E3 ubiquitin ligases Mindbomb1 (Mib1) and Neuralized (Neur) regulate the ubiquitination of Dl and Ser and thereby promote both ligand endocytosis and Notch receptor activation. In this study, we identify the alpha1,4-N-acetylgalactosaminyltransferase-1 (alpha4GT1) gene as a gain of function suppressor of Mib1 inhibition. Expression of alpha4GT1 suppressed the signaling and endocytosis defects of Dl and Ser resulting from the inhibition of mib1 and/or neur activity. Genetic and biochemical evidence indicate that alpha4GT1 plays a regulatory but nonessential function in Notch signaling via the synthesis of a specific glycosphingolipid (GSL), N5, produced by alpha4GT1. Furthermore, we show that the extracellular domain of Ser interacts with GSLs in vitro via a conserved GSL-binding motif, raising the possibility that direct GSL-protein interactions modulate the endocytosis of Notch ligands. Together, our data indicate that specific GSLs modulate the signaling activity of Notch ligands.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.