ArticleMolecular and cellular biology2010
Drosophila RB proteins repress differentiation-specific genes via two different mechanisms.
Article in Molecular and cellular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- A novel role for the 3'-5' exoribonuclease Dis3L2 in controlling cell proliferation and tissue growth.RNA biology · 2016Article
- The pro-apoptotic activity of Drosophila Rbf1 involves dE2F2-dependent downregulation of diap1 and buffy mRNA.Cell death & disease · 2014Article
- Opposing activities of DRM and MES-4 tune gene expression and X-chromosome repression in Caenorhabditis elegans germ cells.G3 (Bethesda, Md.) · 2014Article
- A functional insulator screen identifies NURF and dREAM components to be required for enhancer-blocking.PloS one · 2014Article
- The CHR site: definition and genome-wide identification of a cell cycle transcriptional element.Nucleic acids research · 2014Article
- The complex containing Drosophila Myb and RB/E2F2 regulates cytokinesis in a histone H2Av-dependent manner.Molecular and cellular biology · 2013Article
- Loss of RBF1 changes glutamine catabolism.Genes & development · 2013Article
- Evidence for autoregulation and cell signaling pathway regulation from genome-wide binding of the Drosophila retinoblastoma protein.G3 (Bethesda, Md.) · 2012Article
- A dual role for the dREAM/MMB complex in the regulation of differentiation-specific E2F/RB target genes.Molecular and cellular biology · 2012Article
- Tissue-specific gene targeting by the multiprotein mammalian DREAM complex.The Journal of biological chemistry · 2011Article
- Chromosome-biased binding and gene regulation by the Caenorhabditis elegans DRM complex.PLoS genetics · 2011Article
- Genetic modulation of Rpd3 expression impairs long-term courtship memory in Drosophila.PloS one · 2011Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The RB and E2F proteins play important roles in the regulation of cell division, cell death, and development by controlling the expression of genes involved in these processes. The mechanisms of repression by the retinoblastoma protein (pRB) have been extensively studied at cell cycle-regulated promoters. However, little is known about developmentally regulated E2F/RB genes. Here, we have taken advantage of the simplicity of the E2F/RB pathway in flies to inspect the regulation of differentiation-specific target genes. These genes are repressed by dE2F2/RBF and a recently identified RB-containing complex, dREAM/MMB, in a cell type- and cell cycle-independent manner. Our studies indicate that the mechanism of repression differs from that of cell cycle-regulated genes. We find that two different activities are involved in their regulation and that in proliferating cells, both are required to maintain repression. First, dE2F2/RBF and dREAM/MMB employ histone deacetylase (HDAC) activities at promoter regions. Remarkably, we have also uncovered an unconventional mechanism of repression by the Polycomb group (PcG) protein Enhancer of zeste [E(Z)], which is involved in silencing of these genes through the dimethylation of histone H3 Lys27 at nucleosomes located downstream of the transcription start sites (TSS).
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