ReviewFrontiers in neuroendocrinology2010
Neural mechanisms of reproduction in females as a predisposing factor for drug addiction.
Review in Frontiers in neuroendocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Exercise Modifies the Brain Metabolic Response to Chronic Cocaine Exposure Inhibiting the Stria Terminalis.Brain sciences · 2023Article
- Sex Differences in Cocaine Sensitization Vary by Mouse Strain.Neuroendocrinology · 2023Article
- Hormones can influence drug addiction-A narrative review.BioMedicine · 2021Review
- Membrane estrogen receptor signaling impacts the reward circuitry of the female brain to influence motivated behaviors.Steroids · 2018Review
- Effects of Sex Steroids in the Human Brain.Molecular neurobiology · 2017Review
- Measuring In Vivo Changes in Extracellular Neurotransmitters During Naturally Rewarding Behaviors in Female Syrian Hamsters.Journal of visualized experiments : JoVE · 2017Article
- Estradiol impacts the endocannabinoid system in female rats to influence behavioral and structural responses to cocaine.Neuropharmacology · 2016Article
- Article
- Cell-type specific increases in female hamster nucleus accumbens spine density following female sexual experience.Brain structure & function · 2014Article
- Further characterization of quinpirole-elicited yawning as a model of dopamine D3 receptor activation in male and female monkeys.The Journal of pharmacology and experimental therapeutics · 2014Article
- Vesicular glutamate transporter 2 and tyrosine hydroxylase are not co-localized in Syrian hamster nucleus accumbens afferents.Neuroscience letters · 2013Article
- ΔJunD overexpression in the nucleus accumbens prevents sexual reward in female Syrian hamsters.Genes, brain, and behavior · 2013Article
- The effects of vasopressin and oxytocin on methamphetamine-induced place preference behaviour in rats.Metabolic brain disease · 2012Article
- Building a better hormone therapy? How understanding the rapid effects of sex steroid hormones could lead to new therapeutics for age-related memory decline.Behavioral neuroscience · 2012Review
- Estradiol Facilitation of Cocaine Self-Administration in Female Rats Requires Activation of mGluR5.eNeuroArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
There is an increasing awareness that adolescent females differ from males in their response to drugs of abuse and consequently in their vulnerability to addiction. One possible component of this vulnerability to drug addiction is the neurobiological impact that reproductive physiology and behaviors have on the mesolimbic dopamine system, a key neural pathway mediating drug addiction. In this review, we examine animal models that address the impact of ovarian cyclicity, sexual affiliation, sexual behavior, and maternal care on the long-term plasticity of the mesolimbic dopamine system. The thesis is that this plasticity in synaptic neurotransmission stemming from an individual's normal life history contributes to the pathological impact of drugs of abuse on the neurobiology of this system. Hormones released during reproductive cycles have only transient effects on these dopamine systems, whereas reproductive behaviors produce a persistent sensitization of dopamine release and post-synaptic neuronal responsiveness. Puberty itself may not represent a neurobiological risk factor for drug abuse, but attendant behavioral experiences may have a negative impact on females engaging in drug use.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.